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Literature DB >> 11869898

Somatic immunoglobulin hypermutation.

Abstract

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

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Year: 2002 PMID： 11869898 PMCID： PMC4621002 DOI： 10.1016/s0952-7915(02)00327-8

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

55 in total

Review 1. Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.

Authors: U Storb; H M Shen; N Michael; N Kim
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-01-29 Impact factor: 6.237

2. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.

Authors: X Zeng; D B Winter; C Kasmer; K H Kraemer; A R Lehmann; P J Gearhart
Journal: Nat Immunol Date: 2001-06 Impact factor: 25.606

3. Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

Authors: I B Rogozin; Y I Pavlov; K Bebenek; T Matsuda; T A Kunkel
Journal: Nat Immunol Date: 2001-06 Impact factor: 25.606

4. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.

Authors: S Frey; B Bertocci; F Delbos; L Quint; J C Weill; C A Reynaud
Journal: Immunity Date: 1998-07 Impact factor: 31.745

Review 5. Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p.

Authors: C W Lawrence; V M Maher
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-01-29 Impact factor: 6.237

Review 6. DNA polymerase iota and related rad30-like enzymes.

Authors: J P McDonald; A Tissier; E G Frank; S Iwai; F Hanaoka; R Woodgate
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-01-29 Impact factor: 6.237

7. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

Authors: A Peters; U Storb
Journal: Immunity Date: 1996-01 Impact factor: 31.745

8. Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J.

Authors: J S Weber; J Berry; T Manser; J L Claflin
Journal: J Immunol Date: 1994-10-15 Impact factor: 5.422

9. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

Authors: P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Labelouse; A Gennery; I Tezcan; F Ersoy; H Kayserili; A G Ugazio; N Brousse; M Muramatsu; L D Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy
Journal: Cell Date: 2000-09-01 Impact factor: 41.582

10. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.

Authors: Q H Phung; D B Winter; A Cranston; R E Tarone; V A Bohr; R Fishel; P J Gearhart
Journal: J Exp Med Date: 1998-06-01 Impact factor: 14.307

33 in total

1. A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.

Authors: Xiaoping Wu; Connie Y Tsai; Marienida B Patam; Hong Zan; Jessica P Chen; Steve M Lipkin; Paolo Casali
Journal: J Immunol Date: 2006-05-01 Impact factor: 5.422

2. The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.

Authors: Hong Zan; Naoko Shima; Zhenming Xu; Ahmed Al-Qahtani; Albert J Evinger Iii; Yuan Zhong; John C Schimenti; Paolo Casali
Journal: EMBO J Date: 2005-10-13 Impact factor: 11.598

Review 3. DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.

Authors: Zhenming Xu; Zsolt Fulop; Yuan Zhong; Albert J Evinger; Hong Zan; Paolo Casali
Journal: Ann N Y Acad Sci Date: 2005-06 Impact factor: 5.691

4. Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire.

Authors: C E H Lee; B Gaëta; H R Malming; M E Bain; W A Sewell; A M Collins
Journal: Immunogenetics Date: 2006-01-10 Impact factor: 2.846

Review 5. DNA replication to aid somatic hypermutation.

Authors: Zhenming Xu; Hong Zan; Zsuzsanna Pal; Paolo Casali
Journal: Adv Exp Med Biol Date: 2007 Impact factor: 2.622

6. Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.

Authors: Atsumasa Komori; Zhenming Xu; Xiaoping Wu; Hong Zan; Paolo Casali
Journal: Mol Immunol Date: 2006-01-10 Impact factor: 4.407

10. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.

Authors: Seok-Rae Park; Hong Zan; Zsuzsanna Pal; Jinsong Zhang; Ahmed Al-Qahtani; Egest J Pone; Zhenming Xu; Thach Mai; Paolo Casali
Journal: Nat Immunol Date: 2009-04-12 Impact factor: 25.606