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Literature DB >> 8608811

Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.

Abstract

Treatment of alloxan diabetic rats with the antioxidant S-allyl cysteine sulfoxide (SACS) isolated from garlic (Allium sativum Linn), ameliorated the diabetic condition almost to the same extent as did glibenclamide and insulin. In addition, SACS controlled lipid peroxidation better than the other two drugs. Furthermore, SACS significantly stimulated in vitro insulin secretion from B cells isolated from normal rats. Hence it can be surmised that the beneficial effects of SACS could be due to both its antioxidant and its secretagogue actions. The former effect is more predominant and the latter is only secondary. These effects highlight the therapeutic value of garlic, which is a component of many diets.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8608811 DOI： 10.1007/bf01923354

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

25 in total

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42 in total

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Authors: A Hosseini; H Hosseinzadeh
Journal: J Endocrinol Invest Date: 2015-06-03 Impact factor: 4.256

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Journal: Curr Med Chem Date: 2011 Impact factor: 4.530

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Authors: Ali Zeybek; Feriha Ercan; Sule Cetinel; Esra Cikler; Beyhan Saglam; Göksel Sener
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Authors: Nathchar Naowarojna; Ronghai Cheng; Li Chen; Melissa Quill; Meiling Xu; Changming Zhao; Pinghua Liu
Journal: Biochemistry Date: 2018-04-06 Impact factor: 3.162

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Journal: Lab Invest Date: 2009-09-21 Impact factor: 5.662