Literature DB >> 26036599

A review on the effects of Allium sativum (Garlic) in metabolic syndrome.

A Hosseini1, H Hosseinzadeh2.   

Abstract

The metabolic syndrome is a common problem world-wide and includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia disorders. It leads to insulin resistance and the development of diabetes mellitus or cardiovascular disease. Allium sativum (garlic) has been documented to exhibit anti-diabetic, hypotensive, and hypolipidemic properties. This suggests a potential role of A. sativum in the management of metabolic syndrome; however, more studies should be conducted to evaluate its effectiveness. In this review, we discussed the most relevant articles to find out the role of A. sativum in different components of metabolic syndrome and cardiovascular disease risk factors. Because human reports are rare, further studies are required to establish the clinical value of A. sativum in metabolic syndrome.

Entities:  

Keywords:  Allium sativum; Cardiovascular disease; Diabetes; Dyslipidemia; Garlic; Hypertension; Metabolic syndrome; Obesity

Mesh:

Substances:

Year:  2015        PMID: 26036599     DOI: 10.1007/s40618-015-0313-8

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN: 0391-4097            Impact factor:   4.256


  93 in total

1.  Molecular basis by which garlic suppresses atherosclerosis.

Authors:  J H Campbell; J L Efendy; N J Smith; G R Campbell
Journal:  J Nutr       Date:  2001-03       Impact factor: 4.798

2.  Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries.

Authors:  David D Ku; Tarek T Abdel-Razek; Jun Dai; SangAe Kim-Park; Michael B Fallon; Gary A Abrams
Journal:  Clin Exp Pharmacol Physiol       Date:  2002 Jan-Feb       Impact factor: 2.557

3.  The antihypertensive effect of garlic (Allium sativum) in the rat two-kidney--one-clip Goldblatt model.

Authors:  K K Al-Qattan; M A Alnaqeeb; M Ali
Journal:  J Ethnopharmacol       Date:  1999-08       Impact factor: 4.360

4.  Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet.

Authors:  M Ali; K K Al-Qattan; F Al-Enezi; R M Khanafer; T Mustafa
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2000-04       Impact factor: 4.006

5.  Antihypertensive properties of Allium sativum (garlic) on normotensive and two kidney one clip hypertensive rats.

Authors:  C R Nwokocha; R I Ozolua; D U Owu; M I Nwokocha; A C Ugwu
Journal:  Niger J Physiol Sci       Date:  2011-12-20

6.  Interleukin-10 to tumor necrosis factor-alpha ratio is a predictive biomarker in nonalcoholic fatty liver disease: interleukin-10 to tumor necrosis factor-alpha ratio in steatohepatitis.

Authors:  Reem M Hashem; Mona F Mahmoud; Mohamed A El-Moselhy; Hala M Soliman
Journal:  Eur J Gastroenterol Hepatol       Date:  2008-10       Impact factor: 2.566

7.  Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits.

Authors:  A Bordia; S K Verma; A K Vyas; B L Khabya; A S Rathore; N Bhu; H K Bedi
Journal:  Atherosclerosis       Date:  1977-03       Impact factor: 5.162

8.  Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats.

Authors:  Muhamed Osman; Ariza Adnan; Nor Salmah Bakar; Fatma Alashkham
Journal:  Pol J Pathol       Date:  2012-12       Impact factor: 1.072

9.  Effects of garlic extract consumption on plasma and erythrocyte antioxidant parameters in atherosclerotic patients.

Authors:  Ilker Durak; Bilal Aytaç; Yusuf Atmaca; Erdinç Devrim; Aslihan Avci; Cetin Erol; Derviş Oral
Journal:  Life Sci       Date:  2004-09-03       Impact factor: 5.037

10.  Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.

Authors:  K T Augusti; C G Sheela
Journal:  Experientia       Date:  1996-02-15
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  23 in total

1.  Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.

Authors:  Wenqi Gao; Wei Wang; Jing Zhang; Pengyi Deng; Jun Hu; Jian Yang; Zhifang Deng
Journal:  Metab Brain Dis       Date:  2019-06-14       Impact factor: 3.584

Review 2.  Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review.

Authors:  Faezeh Vahdati Hassani; Kobra Shirani; Hossein Hosseinzadeh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-05-13       Impact factor: 3.000

3.  Assessment of antibacterial effect of garlic in patients infected with Helicobacter pylori using urease breath test.

Authors:  Mahmoud Zardast; Kokab Namakin; Jamil Esmaelian Kaho; Sarira Sadat Hashemi
Journal:  Avicenna J Phytomed       Date:  2016 Sep-Oct

Review 4.  Cinnamon effects on metabolic syndrome: a review based on its mechanisms.

Authors:  Hamid Mollazadeh; Hossein Hosseinzadeh
Journal:  Iran J Basic Med Sci       Date:  2016-12       Impact factor: 2.699

Review 5.  Anti-Inflammatory and Anti-Obesity Properties of Food Bioactive Components: Effects on Adipose Tissue.

Authors:  Shasika Jayarathne; Iurii Koboziev; Oak-Hee Park; Wilna Oldewage-Theron; Chwan-Li Shen; Naima Moustaid-Moussa
Journal:  Prev Nutr Food Sci       Date:  2017-12-31

6.  Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation.

Authors:  Liming Yu; Wencheng Di; Xue Dong; Zhi Li; Xiaodong Xue; Jian Zhang; Qi Wang; Xiong Xiao; Jinsong Han; Yang Yang; Huishan Wang
Journal:  Oncotarget       Date:  2017-08-24

Review 7.  A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome.

Authors:  Jamshid Tabeshpour; Mohsen Imenshahidi; Hossein Hosseinzadeh
Journal:  Iran J Basic Med Sci       Date:  2017-05       Impact factor: 2.699

Review 8.  Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being.

Authors:  Yawen Zeng; Yuping Li; Jiazhen Yang; Xiaoying Pu; Juan Du; Xiaomeng Yang; Tao Yang; Shuming Yang
Journal:  Evid Based Complement Alternat Med       Date:  2017-02-05       Impact factor: 2.629

Review 9.  A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome.

Authors:  Setareh Sanati; Bibi Marjan Razavi; Hossein Hosseinzadeh
Journal:  Iran J Basic Med Sci       Date:  2018-05       Impact factor: 2.699

Review 10.  Effect of eggplant (Solanum melongena) on the metabolic syndrome: A review.

Authors:  Fatemeh Yarmohammadi; Mahboobeh Ghasemzadeh Rahbardar; Hossein Hosseinzadeh
Journal:  Iran J Basic Med Sci       Date:  2021-04       Impact factor: 2.699

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