Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.

Literature DB >> 8592987

Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.

D M Gakunju¹, E K Mberu, S F Dossaji, A I Gray, R D Waigh, P G Waterman, W M Watkins.

Abstract

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.

Entities: Chemical Species

Mesh：

Substances：

Year: 1995 PMID： 8592987 PMCID： PMC162997 DOI： 10.1128/AAC.39.12.2606

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Antimalarial activity of Tanzanian medicinal plants.

Authors: H Weenen; M H Nkunya; D H Bray; L B Mwasumbi; L S Kinabo; V A Kilimali
Journal: Planta Med Date: 1990-08 Impact factor: 3.352

2. Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants.

Authors: M J O'neill; D H Bray; P Boardman; J D Phillipson; D C Warhurst
Journal: Planta Med Date: 1985-10 Impact factor: 3.352

3. Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae).

Authors: W M Messmer; M Tin-Wa; H H Fong; C Bevelle; N R Farnsworth; D J Abraham; J Trojánek
Journal: J Pharm Sci Date: 1972-11 Impact factor: 3.534

4. Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania.

Authors: P L Alonso; T Smith; J R Schellenberg; H Masanja; S Mwankusye; H Urassa; I Bastos de Azevedo; J Chongela; S Kobero; C Menendez
Journal: Lancet Date: 1994-10-29 Impact factor: 79.321

5. In vitro antimalarial activity of tetrahydrofolate dehydrogenase inhibitors.

Authors: D G Sixsmith; W M Watkins; J D Chulay; H C Spencer
Journal: Am J Trop Med Hyg Date: 1984-09 Impact factor: 2.345

6. Drug sensitivity of plasmodium falciparum. An in-vitro microtechnique.

Authors: K H Rieckmann; G H Campbell; L J Sax; J E Mrema
Journal: Lancet Date: 1978-01-07 Impact factor: 79.321

7. The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.

Authors: W M Watkins; D G Sixsmith; J D Chulay
Journal: Ann Trop Med Parasitol Date: 1984-06

8. Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya.

Authors: W M Watkins; D G Sixsmith; H C Spencer; D A Boriga; D M Kariuki; T Kipingor; D K Koech
Journal: Lancet Date: 1984-02-18 Impact factor: 79.321

9. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors: R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal: Antimicrob Agents Chemother Date: 1979-12 Impact factor: 5.191

10. The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II.

Authors: A K Larsen; L Grondard; J Couprie; B Desoize; L Comoe; J C Jardillier; J F Riou
Journal: Biochem Pharmacol Date: 1993-10-19 Impact factor: 5.858

18 in total

1. Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride.

Authors: L P Li; F F Song; Y Y Weng; X Yang; K Wang; H M Lei; J Ma; H Zhou; H D Jiang
Journal: Br J Pharmacol Date: 2016-07-09 Impact factor: 8.739

Review 2. Biologically active quinoline and quinazoline alkaloids part II.

Authors: Xiao-Fei Shang; Susan L Morris-Natschke; Guan-Zhou Yang; Ying-Qian Liu; Xiao Guo; Xiao-Shan Xu; Masuo Goto; Jun-Cai Li; Ji-Yu Zhang; Kuo-Hsiung Lee
Journal: Med Res Rev Date: 2018-02-27 Impact factor: 12.944

3. Fluorescence properties of selected benzo[c]phenanthridines.

Authors: Kamil Motyka; Jakub Stýskala; Petr Cankař; Jan Hlaváč
Journal: J Fluoresc Date: 2014-05-06 Impact factor: 2.217

Review 4. Antiplasmodial natural products: an update.

Authors: Nasir Tajuddeen; Fanie R Van Heerden
Journal: Malar J Date: 2019-12-05 Impact factor: 2.979

5. Antimalarial Natural Products.

Authors: David G I Kingston; Maria Belen Cassera
Journal: Prog Chem Org Nat Prod Date: 2022

6. Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine.

Authors: El-Hadi M Ahmed; Bakri Y M Nour; Yousif G Mohammed; Hassan S Khalid
Journal: Environ Health Insights Date: 2010-02-04

7. Biological activities of nitidine, a potential anti-malarial lead compound.

Authors: Jérome Bouquet; Marion Rivaud; Séverine Chevalley; Eric Deharo; Valérie Jullian; Alexis Valentin
Journal: Malar J Date: 2012-03-09 Impact factor: 2.979

Review 8. The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.

Authors: Pascal Amoa Onguéné; Fidele Ntie-Kang; Lydia Likowo Lifongo; Jean Claude Ndom; Wolfgang Sippl; Luc Meva'a Mbaze
Journal: Malar J Date: 2013-12-13 Impact factor: 2.979

9. Multiple shoot regeneration and effect of sugars on growth and nitidine accumulation in shoot cultures of Toddalia asiatica.

Authors: Chinthala Praveena; Ciddi Veeresham
Journal: Pharmacogn Mag Date: 2014-08 Impact factor: 1.085

Review 10. Natural products targeting cancer cell dependency.

Authors: Changxiang Shi; Eun Ju Yang; Shishi Tao; Guowen Ren; Pui Kei Mou; Joong Sup Shim
Journal: J Antibiot (Tokyo) Date: 2021-06-23 Impact factor: 2.649