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Literature DB >> 24796969

Fluorescence properties of selected benzo[c]phenanthridines.

Kamil Motyka¹, Jakub Stýskala, Petr Cankař, Jan Hlaváč.

Abstract

The fluorescence properties of selected benzo[c]phenanthridines (BPs) were examined. The effect of structure, pH and solvent on the fluorescence properties has been investigated. It was found out that the presence of charged iminium nitrogen significantly decreased the fluorescence of the compounds. The fluorescence (intensity as well as emission spectra shape) of the investigated compounds was significantly dependent on pH as well as used solvent. The utilization in epigenetic modification mechanisms studies as demethylase probe and as possible pH indicator was suggested.

Entities: Chemical

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Year: 2014 PMID： 24796969 DOI： 10.1007/s10895-014-1398-8

Source DB: PubMed Journal: J Fluoresc ISSN： 1053-0509 Impact factor: 2.217

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References

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Fluorescence properties of selected benzo[c]phenanthridines.

1. Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.

2. Synthesis of derivatives of NK109, 7-OH benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties.

3. Influence of DNA structures on the conversion of sanguinarine alkanolamine form to iminium form.

4. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.

5. Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens.

6. Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms.

7. Revision of the structure of fagaridine based on the comparison of UV and NMR data of synthetic compounds.

8. Inhibition of topoisomerase I function by nitidine and fagaronine.

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10. Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.