Literature DB >> 858627

UV-light induced sister chromatid exchanges in xeroderma pigmentosum lymphocytes.

A D Schönwald, E Passarge.   

Abstract

Cultured lymphocytes from 9 patients with clinically different types of xeroderma pigmentosum were exposed to ultraviolet light at 24 h. An increased rate of sister chromatid exchanges were observed in 6 patients (128--148% increase in three, 34--51% in three), but not in three patients with deSanctis-Cacchione syndrome (xeroderma pigmentosum with mental defect), compared to simultaneously cultured controls. A positive result could be useful as preliminary cytogenetic diagnostic test. The results are interpreted as an expression of UV-light induced chromosomal instability due to impaired DNA repair.

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Year:  1977        PMID： 858627     DOI： 10.1007/BF00273260

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

Review 1.  Xeroderma pigmentosum: biochemical and genetic characteristics.

Authors:  J E Cleaver; D Bootsma
Journal:  Annu Rev Genet       Date:  1975       Impact factor: 16.830

2.  Genetic heterogeneity in xeroderma pigmentosum: complementation groups and their relationship to DNA repair rates.

Authors:  K H Kraemer; H G Coon; R A Petinga; S F Barrett; A E Rahe; J H Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

3.  Prenatal diagnosis of xeroderma pigmentosum. Report of the first successful case.

Authors:  C A Ramsay; T M Coltart; S Blunt; S A Pawsey; F Giannelli
Journal:  Lancet       Date:  1974-11-09       Impact factor: 79.321

4.  Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.

Authors:  S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

5.  Insights on chromosome structure from sister chromatid exchange ratios and the lack of both isolabelling and heterolabelling as determined by the FPG technique.

Authors:  S H Wolff; P Perry
Journal:  Exp Cell Res       Date:  1975-06       Impact factor: 3.905

6.  Differential Giemsa staining of sister chromatids and the study of chromatid exchanges without autoradiography.

Authors:  S Wolff; P Perry
Journal:  Chromosoma       Date:  1974       Impact factor: 4.316

7.  Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

Authors:  P Perry; H J Evans
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962

Review 8.  Postreplication repair of DNA in mammalian cells.

Authors:  A R Lehmann
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037

9.  Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

Authors:  A R Lehmann; S Kirk-Bell; C F Arlett; M C Paterson; P H Lohman; E A de Weerd-Kastelein; D Bootsma
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

10.  Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme.

Authors:  B M Sutherland; M Rice; E K Wagner
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205
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  10 in total

1.  Ultraviolet light-induced chromosomal aberrations in cultured cells from Cockayne syndrome and complementation group C xeroderma pigmentosum patients: lack of correlation with cancer susceptibility.

Authors:  L R Seguin; R E Tarone; K H Liao; J H Robbins
Journal:  Am J Hum Genet       Date:  1988-03       Impact factor: 11.025

Review 2.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

Review 3.  Dna repair: pathways and defects.

Authors:  C R Bartram
Journal:  Eur J Pediatr       Date:  1980-12       Impact factor: 3.183

Review 4.  Sister chromatid exchange analysis.

Authors:  S A Latt; R R Schreck
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

5.  Functional deficiency of fibroblasts heterozygous for Bloom syndrome as specific manifestation of the primary defect.

Authors:  C R Bartram; H W Rüdiger; U Schmidt-Preuss; E Passarge
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025

6.  Risk factors of the cutaneous melanoma phenotype.

Authors:  E G Jung; K Günthart; R F Metzger; E Bohnert
Journal:  Arch Dermatol Res       Date:  1981       Impact factor: 3.017

7.  Demonstration of heterogeneity in xeroderma pigmentosum.

Authors:  M A Kim; H Traupe
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017

8.  Sister chromatid exchange (SCE) in human lymphocytes. Effect of UV C irradiation and age.

Authors:  F Zanzoni; J W Baumann; E G Jung
Journal:  Arch Dermatol Res       Date:  1979-07-30       Impact factor: 3.017

9.  Increase of sister chromatid exchanges in excision repair deficient xeroderma pigmentosum.

Authors:  R Aledo; G Renault; M Prieur; M F Avril; B Chrétien; B Dutrillaux; A Aurias
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

10.  Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro.

Authors:  F Zanzoni; E G Jung
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017
  10 in total

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