Literature DB >> 1054487

Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme.

B M Sutherland, M Rice, E K Wagner.   

Abstract

Fibroblasts from patients with xeroderma pigmentosum contain low levels of photoreactivating enzyme in comparison to normal cells. Levels vary from 0 (line 1199) to 50 (line 1259) percent of normal. The depressed enzyme levels are not an artifact of low growth rate, age of cell donor, cell culture conditions, assay conditions, the presence of inhibitors, or mycoplasma contamination. We show that human fibroblasts can monomerize pyrimidine dimers in vivo.

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Year:  1975        PMID： 1054487      PMCID： PMC432249          DOI： 10.1073/pnas.72.1.103

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  A rapid and sensitive assay for pyrimidine dimers in DNA.

Authors:  B M Sutherland; M J Chamberlin
Journal:  Anal Biochem       Date:  1973-05       Impact factor: 3.365

3.  Evidence for transcriptional control of the herpes simplex virus genome in infected human cells.

Authors:  E K Wagner
Journal:  Virology       Date:  1972-02       Impact factor: 3.616

4.  Photoreactivating enzyme from human leukocytes.

Authors:  B M Sutherland
Journal:  Nature       Date:  1974-03-08       Impact factor: 49.962

5.  Xeroderma pigmentosum. An inherited diseases with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair.

Authors:  J H Robbins; K H Kraemer; M A Lutzner; B W Festoff; H G Coon
Journal:  Ann Intern Med       Date:  1974-02       Impact factor: 25.391

6.  Xeroderma pigmentosum epidermal cells with normal UV-induced thymidine incorporation.

Authors:  J H Robbins; W R Levis; A E Miller
Journal:  J Invest Dermatol       Date:  1972-11       Impact factor: 8.551

7.  Photoreactivating-enzyme activity in metazoa.

Authors:  J S Cook; J R McGrath
Journal:  Proc Natl Acad Sci U S A       Date:  1967-10       Impact factor: 11.205

8.  Rapid detection of mycoplasma-infected cell cultures.

Authors:  G J Todaro; S A Aaronson; E Rands
Journal:  Exp Cell Res       Date:  1971-03       Impact factor: 3.905

9.  Incorporation of 3H-uridine and 3H-uracil into RNA: a simple technique for the detection of mycoplasma contamination of cultured cells.

Authors:  E L Schneider; E J Stanbridge; C J Epstein
Journal:  Exp Cell Res       Date:  1974-03-15       Impact factor: 3.905

10.  The effect of x-rays and ultraviolet light on the uptake in vitro of [8-14C]adenine and [2-14C]phenylalanine by isolated nuclei.

Authors:  R LOGAN; M ERRERA; A FICQ
Journal:  Biochim Biophys Acta       Date:  1959-03
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  17 in total

1.  Mapping early transcripts of herpes simplex virus type 1 by electron microscopy.

Authors:  J R Stringer; L E Holland; E K Wagner
Journal:  J Virol       Date:  1978-07       Impact factor: 5.103

2.  An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts.

Authors:  U Kuhnlein; E E Penhoet; S Linn
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

3.  Tumours of the skin.

Authors:  F Giannelli
Journal:  Proc R Soc Med       Date:  1977-06

4.  Isolation and characterization of a photorepair-deficient mutant in Drosophila melanogaster.

Authors:  J B Boyd; P V Harris
Journal:  Genetics       Date:  1987-06       Impact factor: 4.562

5.  Different rate-limiting steps in excision repair of ultraviolet- and N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human fibroblasts.

Authors:  F E Ahmed; R B Setlow
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

6.  UV-light induced sister chromatid exchanges in xeroderma pigmentosum lymphocytes.

Authors:  A D Schönwald; E Passarge
Journal:  Hum Genet       Date:  1977-04-15       Impact factor: 4.132

Review 7.  Dna repair: pathways and defects.

Authors:  C R Bartram
Journal:  Eur J Pediatr       Date:  1980-12       Impact factor: 3.183

8.  Study of DNA repair on a xeroderma pigmentosum patient and his heterozygotic parents.

Authors:  M Went; A Kenderessy-Szabó; A Polay; N Simon
Journal:  Arch Dermatol Res       Date:  1981       Impact factor: 3.017

9.  Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.

Authors:  K Tanaka; H Hayakawa; M Sekiguchi; Y Okada
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

10.  Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km.

Authors:  U Kuhnlein; B Lee; E E Penhoet; S Linn
Journal:  Nucleic Acids Res       Date:  1978-03       Impact factor: 16.971
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