Literature DB >> 8538762

Requirement for Xist in X chromosome inactivation.

G D Penny1, G F Kay, S A Sheardown, S Rastan, N Brockdorff.   

Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8538762     DOI： 10.1038/379131a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  488 in total

1.  Further examination of the Xist promoter-switch hypothesis in X inactivation: evidence against the existence and function of a P(0) promoter.

Authors:  D Warshawsky; N Stavropoulos; J T Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression.

Authors:  E Debrand; C Chureau; D Arnaud; P Avner; E Heard
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

3.  Promoter-specific hypoacetylation of X-inactivated genes.

Authors:  S L Gilbert; P A Sharp
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

4.  Chromatin structure analysis of the mouse Xist locus.

Authors:  V McCabe; E J Formstone; L P O'Neill; B M Turner; N Brockdorff
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

5.  Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis.

Authors:  J A Bailey; L Carrel; A Chakravarti; E E Eichler
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

Review 6.  Sex Chromosome Genetics '99. The X chromosome and recurrent spontaneous abortion: the significance of transmanifesting carriers.

Authors:  M C Lanasa; W A Hogge; E P Hoffman
Journal:  Am J Hum Genet       Date:  1999-04       Impact factor: 11.025

7.  Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies.

Authors:  E Heard; F Mongelard; D Arnaud; P Avner
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

8.  Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.

Authors:  S Luikenhuis; A Wutz; R Jaenisch
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

9.  Making sense (and antisense) of the X inactivation center.

Authors:  H F Willard; L Carrel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

10.  A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.

Authors:  N Stavropoulos; N Lu; J T Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.