Literature DB >> 11481444

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.

N Stavropoulos1, N Lu, J T Lee.   

Abstract

In female mammals, up-regulation of Xist triggers X-chromosome inactivation in cis. Up-regulation is inhibited by sequences 3' to Xist contained within the antisense locus, Tsix. Inhibition could depend on transcription of Tsix and/or on DNA elements therein. Here we test the role of Tsix transcription by augmenting the duration and strength of Tsix expression. We find that Tsix hypertranscription is sufficient to block Xist RNA accumulation in a cis-limited manner. We propose that Tsix transcription is necessary to restrict Xist activity on the future active X and, conversely, that Tsix repression is required for Xist RNA accumulation on the future inactive X. We also find that Tsix hypertranscription does not affect X-chromosome choice. Thus, choice is mediated by elements within Tsix that are independent of promoter activity.

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Year:  2001        PMID： 11481444      PMCID： PMC56944          DOI： 10.1073/pnas.171243598

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Targeted mutagenesis of Tsix leads to nonrandom X inactivation.

Authors:  J T Lee; N Lu
Journal:  Cell       Date:  1999-10-01       Impact factor: 41.582

2.  Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression.

Authors:  E Debrand; C Chureau; D Arnaud; P Avner; E Heard
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

3.  A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation.

Authors:  A Wutz; R Jaenisch
Journal:  Mol Cell       Date:  2000-04       Impact factor: 17.970

4.  X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro.

Authors:  G R Martin; C J Epstein; B Travis; G Tucker; S Yatziv; D W Martin; S Clift; S Cohen
Journal:  Nature       Date:  1978-01-26       Impact factor: 49.962

5.  Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos.

Authors:  M Monk; M I Harper
Journal:  Nature       Date:  1979-09-27       Impact factor: 49.962

6.  Controlling elements in the mouse X chromosome.

Authors:  B M Cattanach; J H Isaacson
Journal:  Genetics       Date:  1967-10       Impact factor: 4.562

Review 7.  Towards a molecular understanding of Prader-Willi and Angelman syndromes.

Authors:  M R Mann; M S Bartolomei
Journal:  Hum Mol Genet       Date:  1999       Impact factor: 6.150

8.  Gene action in the X-chromosome of the mouse (Mus musculus L.).

Authors:  M F LYON
Journal:  Nature       Date:  1961-04-22       Impact factor: 49.962

9.  Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.

Authors:  G R Martin; M J Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

10.  A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.

Authors:  K Okamoto; H Okazawa; A Okuda; M Sakai; M Muramatsu; H Hamada
Journal:  Cell       Date:  1990-02-09       Impact factor: 41.582
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  61 in total

1.  Making sense (and antisense) of the X inactivation center.

Authors:  H F Willard; L Carrel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

2.  The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene.

Authors:  Céline Morey; Pablo Navarro; Emmanuel Debrand; Philip Avner; Claire Rougeulle; Philippe Clerc
Journal:  EMBO J       Date:  2004-01-29       Impact factor: 11.598

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Review 4.  Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control.

Authors:  Jeannie T Lee
Journal:  Nat Rev Mol Cell Biol       Date:  2011-11-23       Impact factor: 94.444

Review 5.  The X as model for RNA's niche in epigenomic regulation.

Authors:  Jeannie T Lee
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-03-31       Impact factor: 10.005

6.  Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.

Authors:  Sha Sun; Bernhard Payer; Satoshi Namekawa; Jee Young An; William Press; Jovani Catalan-Dibene; Hongjae Sunwoo; Jeannie T Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-21       Impact factor: 11.205

7.  Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation.

Authors:  Nicholas Stavropoulos; Rebecca K Rowntree; Jeannie T Lee
Journal:  Mol Cell Biol       Date:  2005-04       Impact factor: 4.272

8.  An essential role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X chromosome inactivation.

Authors:  Sébastien Vigneau; Sandrine Augui; Pablo Navarro; Philip Avner; Philippe Clerc
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-28       Impact factor: 11.205

9.  Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program.

Authors:  Pablo Navarro; Damian R Page; Philip Avner; Claire Rougeulle
Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

10.  Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.

Authors:  Lisa Helbling Chadwick; Lisa M Pertz; Karl W Broman; Marisa S Bartolomei; Huntington F Willard
Journal:  Genetics       Date:  2006-04-02       Impact factor: 4.562
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