Literature DB >> 8523075

Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas.

B G Feuerstein1, G Mohapatra.   

Abstract

The unregulated growth that is characteristic of human malignant gliomas is accompanied by, and may result from, losses and/or gains of genetic material. Understanding the mechanisms that underlie how particular genetic aberrations cause dysfunctional growth will help elucidate the pathogenesis of this disease. Two techniques are proving useful in evaluating the clinical relevance of specific genetic aberrations in malignant gliomas. Fluorescence in situ hybridization (FISH) permits direct visualization of gains and losses of genetic material in single cells and quantitation of cellular subpopulations that have particular genetic aberrations. Comparative genomic hybridization can identify regions of genetic gain and loss in tumor DNA.

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Year:  1995        PMID： 8523075     DOI： 10.1007/bf01052658

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  22 in total

Review 1.  Analytical approaches to detection and characterization of disease-linked chromosome aberrations.

Authors:  J W Gray; W L Kuo; J Liang; D Pinkel; G van den Engh; B Trask; D Tkachuk; F Waldman; C Westbrook
Journal:  Bone Marrow Transplant       Date:  1990-07       Impact factor: 5.483

2.  Interphase cytogenetics reveals somatic pairing of chromosome 17 centromeres in normal human brain tissue, but no trisomy 7 or sex-chromosome loss.

Authors:  E P Arnoldus; I A Noordermeer; A C Peters; A K Raap; M Van der Ploeg
Journal:  Cytogenet Cell Genet       Date:  1991

3.  Gene amplification in malignant human gliomas: clinical and histopathologic aspects.

Authors:  S H Bigner; P C Burger; A J Wong; M H Werner; S R Hamilton; L H Muhlbaier; B Vogelstein; D D Bigner
Journal:  J Neuropathol Exp Neurol       Date:  1988-05       Impact factor: 3.685

4.  Somatic pairing of chromosome 1 centromeres in interphase nuclei of human cerebellum.

Authors:  E P Arnoldus; A C Peters; G T Bots; A K Raap; M van der Ploeg
Journal:  Hum Genet       Date:  1989-10       Impact factor: 4.132

5.  Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.

Authors:  O I Olopade; R B Jenkins; D T Ransom; K Malik; H Pomykala; T Nobori; J M Cowan; J D Rowley; M O Diaz
Journal:  Cancer Res       Date:  1992-05-01       Impact factor: 12.701

6.  Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas.

Authors:  J Q Cheng; S C Jhanwar; Y Y Lu; J R Testa
Journal:  Cancer Res       Date:  1993-10-15       Impact factor: 12.701

7.  Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme.

Authors:  S H Park; T Maeda; G Mohapatra; F M Waldman; R L Davis; B G Feuerstein
Journal:  Cancer Genet Cytogenet       Date:  1995-09

8.  Relationship between gene amplification and chromosomal deviations in malignant human gliomas.

Authors:  S H Bigner; A J Wong; J Mark; L H Muhlbaier; K W Kinzler; B Vogelstein; D D Bigner
Journal:  Cancer Genet Cytogenet       Date:  1987-11

Review 9.  Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors.

Authors:  O P Kallioniemi; A Kallioniemi; D Sudar; D Rutovitz; J W Gray; F Waldman; D Pinkel
Journal:  Semin Cancer Biol       Date:  1993-02       Impact factor: 15.707

10.  Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors.

Authors:  C D James; J He; E Carlbom; M Nordenskjold; W K Cavenee; V P Collins
Journal:  Cancer Res       Date:  1991-03-15       Impact factor: 12.701
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  3 in total

Review 1.  Neuropathology for the neuroradiologist: fluorescence in situ hybridization.

Authors:  F J Wippold; A Perry
Journal:  AJNR Am J Neuroradiol       Date:  2007-03       Impact factor: 3.825

2.  Investigation of genetic alterations associated with development and adverse outcome in patients with astrocytic tumor.

Authors:  A M Cianciulli; E Morace; A M Coletta; E Occhipinti; G M Gandolfo; G Leonardo; C M Carapella
Journal:  J Neurooncol       Date:  2000-06       Impact factor: 4.130

3.  Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.

Authors:  Wallax Augusto Silva Ferreira; Glauco Akelinghton Freire Vitiello; Tiago da Silva Medina; Edivaldo Herculano Correa de Oliveira
Journal:  Sci Rep       Date:  2022-04-19       Impact factor: 4.996
  3 in total

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