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Literature DB >> 849291

The release of alanine by rat diaphragm muscle in vitro.

Abstract

Alanine release by rat diaphragm muscle in vitro is stimulated by glutamate, valine, leucine and glucose. The stimulation by glutamate and valine (but not leucine) is inhibited by 3-mercaptopicolinate. These results suggest a metabolic route involving phosphoenolpyruvate carboxykinase which directs amino acid carbon skeletons towards pyruvate synthesis for alanine formation.

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Year: 1977 PMID： 849291 PMCID： PMC1164613 DOI： 10.1042/bj1620399

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. The role of chemical equilibria in organ function.

Authors: H A Krebs
Journal: Adv Enzyme Regul Date: 1975

2. De novo synthesis of alanine by the perfused rat hindlimb.

Authors: B Grubb
Journal: Am J Physiol Date: 1976-05

3. Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

Authors: P J Blackshear; P A Holloway; K G Alberti
Journal: Biochem J Date: 1975-09 Impact factor: 3.857

Review 4. The glucose-alanine cycle.

Authors: P Felig
Journal: Metabolism Date: 1973-02 Impact factor: 8.694

5. Origin and possible significance of alanine production by skeletal muscle.

Authors: R Odessey; E A Khairallah; A L Goldberg
Journal: J Biol Chem Date: 1974-12-10 Impact factor: 5.157

6. The pathway of gluconeogenesis in the cortex of guinea-pig kidney. Use of aminooxyacetate as a transaminase inhibitor.

Authors: I D Longshaw; N L Bowen; C I Pogson
Journal: Eur J Biochem Date: 1972-02-15

7. Hormone-fuel interrelationships during fasting.

Authors: G F Cahill; M G Herrera; A P Morgan; J S Soeldner; J Steinke; P L Levy; G A Reichard; D M Kipnis
Journal: J Clin Invest Date: 1966-11 Impact factor: 14.808

8. Alanine and glutamine synthesis and release from skeletal muscle. I. Glycolysis and amino acid release.

Authors: A J Garber; I E Karl; D M Kipnis
Journal: J Biol Chem Date: 1976-02-10 Impact factor: 5.157

9. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo.

Authors: A McAllister; S P Allison; P J Randle
Journal: Biochem J Date: 1973-08 Impact factor: 3.857

10. The activities of fructose 1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle.

Authors: L H Opie; E A Newsholme
Journal: Biochem J Date: 1967-05 Impact factor: 3.857

22 in total

1. The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.

Authors: E A Newsholme; T Williams
Journal: Biochem J Date: 1978-11-15 Impact factor: 3.857

Review 2. What is the metabolic role of phosphoenolpyruvate carboxykinase?

Authors: Jianqi Yang; Satish C Kalhan; Richard W Hanson
Journal: J Biol Chem Date: 2009-07-27 Impact factor: 5.157

3. Limitations of commonly used spectrophotometric assay methods for phosphoenolypyruvate carboxykinase activity in crude extracts of muscle.

Authors: D A Duff; K Snell
Journal: Biochem J Date: 1982-07-15 Impact factor: 3.857

4. Amino acid metabolism by perfused rat hindquarter. Effects of insulin, leucine and 2-chloro-4-methylvalerate.

Authors: E J Davis; S H Lee
Journal: Biochem J Date: 1985-07-01 Impact factor: 3.857

5. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.

Authors: Parvin Hakimi; Jianqi Yang; Gemma Casadesus; Duna Massillon; Fatima Tolentino-Silva; Colleen K Nye; Marco E Cabrera; David R Hagen; Christopher B Utter; Yacoub Baghdy; David H Johnson; David L Wilson; John P Kirwan; Satish C Kalhan; Richard W Hanson
Journal: J Biol Chem Date: 2007-08-23 Impact factor: 5.157

6. Interference by branched-chain amino acids in the assay of alanine with alanine dehydrogenase.

Authors: P Lund; G Baverel
Journal: Biochem J Date: 1978-09-15 Impact factor: 3.857

7. Branched-chain amino acid metabolism and alanine formation in rat muscles in vitro. Mitochondrial-cytosolic interrelationships.

Authors: K Snell; D A Duff
Journal: Biochem J Date: 1985-02-01 Impact factor: 3.857

8. Branched-chain amino acid nitrogen transfer to alamine in vivo in dogs. Direct isotopic determination with [15N]leucine.

Authors: E B Galim; K Hruska; D M Bier; D E Matthews; M W Haymond
Journal: J Clin Invest Date: 1980-12 Impact factor: 14.808

9. Amino acid oxidation and alanine production in rat hemidiaphragm in vitro. Effects of dichloroacetate.

Authors: T N Palmer; M A Caldecourt; M C Sugden
Journal: Biochem J Date: 1984-10-01 Impact factor: 3.857

10. Adrenergic inhibition of branched-chain 2-oxo acid dehydrogenase in rat diaphragm muscle in vitro.

Authors: T N Palmer; M A Caldecourt; M C Sugden
Journal: Biochem J Date: 1983-10-15 Impact factor: 3.857