Literature DB >> 217368

The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.

E A Newsholme, T Williams.   

Abstract

Starvation or feeding rats on a high-protein diet, valine or isoleucine, but not leucine, increases the activity of muscle phosphoenolpyruvate carboxykinase, but has no effect on NADP+-linked malate dehydrogenase. This suggests that muscle phosphoenolpyruvate carboxykinase is involved in oxidation or conversion of some amino acids to alanine.

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Year:  1978        PMID： 217368      PMCID： PMC1186277          DOI： 10.1042/bj1760623

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

Review 1.  The role of the fructose 6-phosphate/fructose 1,6-diphosphate cycle in metabolic regulation and heat generation.

Authors:  E A Newsholme
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

Review 2.  Substrate cycles in metabolic regulation and in heat generation.

Authors:  E A Newsholme; B Crabtree
Journal:  Biochem Soc Symp       Date:  1976

Review 3.  Metabolic aspects of enzyme activity regulation.

Authors:  E A Newsholme; B Crabtree
Journal:  Symp Soc Exp Biol       Date:  1973

4.  Origin and possible significance of alanine production by skeletal muscle.

Authors:  R Odessey; E A Khairallah; A L Goldberg
Journal:  J Biol Chem       Date:  1974-12-10       Impact factor: 5.157

5.  Insulin in the regulation of protein turnover in heart and skeletal muscle.

Authors:  L S Jefferson; D E Rannels; B L Munger; H E Morgan
Journal:  Fed Proc       Date:  1974-04

6.  The activities of lipases and carnitine palmitoyltransferase in muscles from vertebrates and invertebrates.

Authors:  B Crabtree; E A Newsholme
Journal:  Biochem J       Date:  1972-12       Impact factor: 3.857

7.  Properties of pyruvate kinase and phosphoenolpyruvate carboxykinase in relation to the direction and regulation of phosphoenolpyruvate metabolism in muscles of the frog and marine invertebrates.

Authors:  V A Zammit; E A Newsholme
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

8.  The Meyerhof quotient and the synthesis of glycogen from lactate in frog and rabbit muscle.

Authors:  J R Bendall; A A Taylor
Journal:  Biochem J       Date:  1970-08       Impact factor: 3.857

9.  The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase and fructose diphosphatase in muscles from vertebrates and invertebrates.

Authors:  B Crabtree; S J Higgins; E A Newsholme
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

10.  The release of alanine by rat diaphragm muscle in vitro.

Authors:  K Snell; D A Duff
Journal:  Biochem J       Date:  1977-02-15       Impact factor: 3.857
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  12 in total

Review 1.  What is the metabolic role of phosphoenolpyruvate carboxykinase?

Authors:  Jianqi Yang; Satish C Kalhan; Richard W Hanson
Journal:  J Biol Chem       Date:  2009-07-27       Impact factor: 5.157

2.  Limitations of commonly used spectrophotometric assay methods for phosphoenolypyruvate carboxykinase activity in crude extracts of muscle.

Authors:  D A Duff; K Snell
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857

3.  Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone-body and glutamine utilization pathways in lymphocytes of the rat.

Authors:  M S Ardawi; E A Newsholme
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

4.  The maximum activities of enzymes that are involved in substrate cycles in liver and muscle of obese mice.

Authors:  E A Newsholme; K Brand; J Lang; J C Stanley; T Williams
Journal:  Biochem J       Date:  1979-08-15       Impact factor: 3.857

5.  White adipose tissue re-growth after partial lipectomy in high fat diet induced obese wistar rats.

Authors:  Allain Amador Bueno; Carlos Alexandre Habitante; Lila Missae Oyama; Débora Estadella; Eliane Beraldi Ribeiro; Cláudia Maria Oller do Nascimento
Journal:  J Physiol Sci       Date:  2010-12-08       Impact factor: 2.781

6.  Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.

Authors:  Parvin Hakimi; Jianqi Yang; Gemma Casadesus; Duna Massillon; Fatima Tolentino-Silva; Colleen K Nye; Marco E Cabrera; David R Hagen; Christopher B Utter; Yacoub Baghdy; David H Johnson; David L Wilson; John P Kirwan; Satish C Kalhan; Richard W Hanson
Journal:  J Biol Chem       Date:  2007-08-23       Impact factor: 5.157

7.  Lactate metabolism in the perfused rat hindlimb.

Authors:  M Shiota; S Golden; J Katz
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

8.  Activities of enzymes of fat and ketone-body metabolism and effects of starvation on blood concentrations of glucose and fat fuels in teleost and elasmobranch fish.

Authors:  V A Zammit; E A Newsholme
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

9.  Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.

Authors:  K Snell; D A Duff
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

10.  Effect of adrenaline and phorbol myristate acetate or bacterial lipopolysaccharide on stimulation of pathways of macrophage glucose, glutamine and O2 metabolism. Evidence for cyclic AMP-dependent protein kinase mediated inhibition of glucose-6-phosphate dehydrogenase and activation of NADP+-dependent 'malic' enzyme.

Authors:  L F Costa Rosa; R Curi; C Murphy; P Newsholme
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857
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