Literature DB >> 8478011

Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter.

M Brüss1, J Kunz, B Lingen, H Bönisch.   

Abstract

The neuronal Na(+)- and Cl(-)-dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant desipramine. The NA-transporter belongs to a new gene family of structurally related Na(+)- and Cl(-)-dependent neurotransmitter transporters. In this study, the chromosomal localization for the gene encoding the human NA-transporter (h-NAT) was determined. By hybridization of a panel of somatic cell hybrids and by fluorescent in situ hybridization to metaphase chromosomes, the hNAT gene was localized on chromosome 16q12.2. In addition, evidence is presented for an intron-exon structure of the gene.

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Year:  1993        PMID： 8478011     DOI： 10.1007/bf00218272

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  11 in total

1.  Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple-color fluorescence in situ hybridization.

Authors:  T Ried; C Lengauer; T Cremer; J Wiegant; A K Raap; M van der Ploeg; P Groitl; M Lipp
Journal:  Genes Chromosomes Cancer       Date:  1992-01       Impact factor: 5.006

Review 2.  Neurotransmitter transporters (plus): a promising new gene family.

Authors:  G R Uhl
Journal:  Trends Neurosci       Date:  1992-07       Impact factor: 13.837

3.  Report of the Second International Workshop on Human Chromosome 16 Mapping.

Authors:  D F Callen; C E Hildebrand; S Reeders
Journal:  Cytogenet Cell Genet       Date:  1992

Review 4.  Molecular genetics of the human Na+/glucose cotransporter.

Authors:  M A Hediger; E Turk; A M Pajor; E M Wright
Journal:  Klin Wochenschr       Date:  1989-09-01

Review 5.  Molecular-biologic basis of manic-depressive illness.

Authors:  J A Egeland
Journal:  Pharmacopsychiatry       Date:  1992-01       Impact factor: 5.788

Review 6.  New molecular genetic studies in the affective disorders.

Authors:  J Mendlewicz
Journal:  Pharmacopsychiatry       Date:  1992-01       Impact factor: 5.788

7.  A general method for isolation of high molecular weight DNA from eukaryotes.

Authors:  N Blin; D W Stafford
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

8.  Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries.

Authors:  P Lichter; T Cremer; J Borden; L Manuelidis; D C Ward
Journal:  Hum Genet       Date:  1988-11       Impact factor: 4.132

9.  Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.

Authors:  T Pacholczyk; R D Blakely; S G Amara
Journal:  Nature       Date:  1991-03-28       Impact factor: 49.962

10.  Binding of 3H-desipramine to the neuronal noradrenaline carrier of rat phaeochromocytoma cells (PC-12 cells).

Authors:  H Bönisch; R Harder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000
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  14 in total

1.  A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.

Authors:  Chun-Hyung Kim; Maureen K Hahn; Yoosook Joung; Susan L Anderson; Angela H Steele; Michelle S Mazei-Robinson; Ian Gizer; Martin H Teicher; Bruce M Cohen; David Robertson; Irwin D Waldman; Randy D Blakely; Kwang-Soo Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-04       Impact factor: 11.205

Review 2.  Sodium ion-dependent transporters for neurotransmitters: a review of recent developments.

Authors:  D M Worrall; D C Williams
Journal:  Biochem J       Date:  1994-02-01       Impact factor: 3.857

3.  Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese population.

Authors:  Chuan-Chia Chang; Ru-Band Lu; Chih-Lun Chen; Chi-Ming Chu; Hsin-An Chang; Cheng-Chang Huang; Yi-Lin Huang; San-Yuan Huang
Journal:  J Psychiatry Neurosci       Date:  2007-03       Impact factor: 6.186

Review 4.  Regulation of monoamine transporters: Role of transporter phosphorylation.

Authors:  Sammanda Ramamoorthy; Toni S Shippenberg; Lankupalle D Jayanthi
Journal:  Pharmacol Ther       Date:  2010-10-15       Impact factor: 12.310

5.  Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.

Authors:  W Retz; M Rösler; C Kissling; S Wiemann; R Hünnerkopf; A Coogan; J Thome; C Freitag
Journal:  J Neural Transm (Vienna)       Date:  2007-11-12       Impact factor: 3.575

Review 6.  Physiological genomics of antidepressant targets: keeping the periphery in mind.

Authors:  R D Blakely
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

Review 7.  Drug transporters in the human blood-placental barrier.

Authors:  Kirsi Vähäkangas; Päivi Myllynen
Journal:  Br J Pharmacol       Date:  2009-09-25       Impact factor: 8.739

8.  Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations.

Authors:  Inna Belfer; Gabriel Phillips; Julie Taubman; Heather Hipp; Robert H Lipsky; Mary-Anne Enoch; Mitchell B Max; David Goldman
Journal:  J Hum Genet       Date:  2004       Impact factor: 3.172

9.  Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16.

Authors:  K Hellevuo; R Berry; J M Sikela; B Tabakoff
Journal:  Hum Genet       Date:  1995-02       Impact factor: 4.132

10.  Comprehensive phenotype/genotype analyses of the norepinephrine transporter gene (SLC6A2) in ADHD: relation to maternal smoking during pregnancy.

Authors:  Geeta A Thakur; Sarojini M Sengupta; Natalie Grizenko; Zia Choudhry; Ridha Joober
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240
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