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Literature DB >> 8431010

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

Entities: Chemical Species

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Year: 1993 PMID： 8431010 PMCID： PMC187619 DOI： 10.1128/AAC.37.1.128

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

Authors: A A Neyfakh; V E Bidnenko; L B Chen
Journal: Proc Natl Acad Sci U S A Date: 1991-06-01 Impact factor: 11.205

2. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.

Authors: Y Ohshita; K Hiramatsu; T Yokota
Journal: Biochem Biophys Res Commun Date: 1990-11-15 Impact factor: 3.575

3. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors: H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal: J Bacteriol Date: 1990-12 Impact factor: 3.490

4. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

Authors: A A Neyfakh
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

5. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.

Authors: G W Kaatz; S M Seo; C A Ruble
Journal: J Infect Dis Date: 1991-05 Impact factor: 5.226

5 in total

97 in total

Review 1. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

Authors: M A Ghannoum; L B Rice
Journal: Clin Microbiol Rev Date: 1999-10 Impact factor: 26.132

2. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system.

Authors: B Fournier; R Aras; D C Hooper
Journal: J Bacteriol Date: 2000-02 Impact factor: 3.490

3. A mutation in the 5' untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus.

Authors: B Fournier; Q C Truong-Bolduc; X Zhang; D C Hooper
Journal: J Bacteriol Date: 2001-04 Impact factor: 3.490

Review 9. Multidrug resistance in bacteria.

Authors: Hiroshi Nikaido
Journal: Annu Rev Biochem Date: 2009 Impact factor: 23.643

10. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus.

Authors: Que Chi Truong-Bolduc; Xiamei Zhang; David C Hooper
Journal: J Bacteriol Date: 2003-05 Impact factor: 3.490

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

1. Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

2. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.

3. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

4. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

5. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.

Review 1. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

2. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system.

3. A mutation in the 5' untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus.

Review 4. Molecular properties of bacterial multidrug transporters.

Review 5. Molecular detection of antimicrobial resistance.

Review 6. Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria.

Review 7. Multidrug evolutionary strategies to reverse antibiotic resistance.

Review 8. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Review 9. Multidrug resistance in bacteria.

10. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus.