Literature DB >> 19231985

Multidrug resistance in bacteria.

Hiroshi Nikaido1.   

Abstract

Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance.

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Year:  2009        PMID： 19231985      PMCID： PMC2839888          DOI： 10.1146/annurev.biochem.78.082907.145923

Source DB:  PubMed          Journal:  Annu Rev Biochem        ISSN： 0066-4154            Impact factor:   23.643


  161 in total

Review 1.  Trimethoprim and sulfonamide resistance.

Authors:  P Huovinen; L Sundström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

Review 2.  Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium.

Authors:  M Vaara
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

Review 3.  Common mechanisms in bacterial conjugation and Ti-mediated T-DNA transfer to plant cells.

Authors:  M Lessl; E Lanka
Journal:  Cell       Date:  1994-05-06       Impact factor: 41.582

Review 4.  Resistance to antibiotics mediated by target alterations.

Authors:  B G Spratt
Journal:  Science       Date:  1994-04-15       Impact factor: 47.728

Review 5.  A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria.

Authors:  T Dinh; I T Paulsen; M H Saier
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

6.  The chromosomal tetracycline resistance locus of Bacillus subtilis encodes a Na+/H+ antiporter that is physiologically important at elevated pH.

Authors:  J Cheng; A A Guffanti; T A Krulwich
Journal:  J Biol Chem       Date:  1994-11-04       Impact factor: 5.157

7.  Emr, an Escherichia coli locus for multidrug resistance.

Authors:  O Lomovskaya; K Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

8.  Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

Authors:  A A Neyfakh; C M Borsch; G W Kaatz
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

Review 9.  Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

Authors:  K J Shaw; P N Rather; R S Hare; G H Miller
Journal:  Microbiol Rev       Date:  1993-03

Review 10.  Integrons: novel DNA elements which capture genes by site-specific recombination.

Authors:  R M Hall; H W Stokes
Journal:  Genetica       Date:  1993       Impact factor: 1.082
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  376 in total

1.  A biosensor-based approach reveals links between efflux pump expression and cell cycle regulation in pleiotropic drug resistance of yeast.

Authors:  Jian Li; Kristen Kolberg; Ulrich Schlecht; Robert P St Onge; Ana Maria Aparicio; Joe Horecka; Ronald W Davis; Maureen E Hillenmeyer; Colin J B Harvey
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157

2.  Coarse-grained simulations of conformational changes in the multidrug efflux transporter AcrB.

Authors:  Yead Jewel; Jin Liu; Prashanta Dutta
Journal:  Mol Biosyst       Date:  2017-09-26

3.  Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

Authors:  Michelle C Swick; Sonia K Morgan-Linnell; Kimberly M Carlson; Lynn Zechiedrich
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

4.  Do we need new antibiotics? The search for new targets and new compounds.

Authors:  Jaroslav Spížek; Jitka Novotná; Tomáš Rezanka; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-11-18       Impact factor: 3.346

5.  Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.

Authors:  Girija Dhamdhere; Ganesh Krishnamoorthy; Helen I Zgurskaya
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

6.  Transforming a drug/H+ antiporter into a polyamine importer by a single mutation.

Authors:  Shlomo Brill; Ofir Sade Falk; Shimon Schuldiner
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-03       Impact factor: 11.205

7.  Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa.

Authors:  Connor J Cooper; Ganesh Krishnamoorthy; David Wolloscheck; John K Walker; Valentin V Rybenkov; Jerry M Parks; Helen I Zgurskaya
Journal:  ACS Infect Dis       Date:  2018-05-25       Impact factor: 5.084

8.  Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.

Authors:  Jinshan Jin; Ying-Hsin Hsieh; Jianmei Cui; Krishna Damera; Chaofeng Dai; Arpana S Chaudhary; Hao Zhang; Hsiuchin Yang; Nannan Cao; Chun Jiang; Martti Vaara; Binghe Wang; Phang C Tai
Journal:  ChemMedChem       Date:  2016-10-18       Impact factor: 3.466

9.  Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.

Authors:  Neil R Stokes; Helena B Thomaides-Brears; Stephanie Barker; James M Bennett; Joanne Berry; Ian Collins; Lloyd G Czaplewski; Vicki Gamble; Paul Lancett; Alastair Logan; Christopher J Lunniss; Hilary Peasley; Stéphanie Pommier; Daniel Price; Carol Smee; David J Haydon
Journal:  Antimicrob Agents Chemother       Date:  2013-09-16       Impact factor: 5.191

10.  Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules.

Authors:  Poochit Nonejuie; Michael Burkart; Kit Pogliano; Joe Pogliano
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-17       Impact factor: 11.205
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