Literature DB >> 8428753

The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21.

P M Kluck1, J Wiegant, R P Jansen, M W Bolk, A K Raap, R Willemze, J E Landegent.   

Abstract

The human interleukin-6 receptor alpha chain (IL6R alpha) gene was regionally mapped to chromosome 1 band q21 by fluorescence in situ hybridization. As hybridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3' non-coding region of the gene. This localization confirms and extends the provisional assignment of the IL6R alpha gene to chromosome 1, for which a panel of somatic cell hybrids was used.

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Year:  1993        PMID： 8428753     DOI： 10.1007/bf00217455

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  13 in total

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2.  Structural design and molecular evolution of a cytokine receptor superfamily.

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 3.  The biology of interleukin-6.

Authors:  T Kishimoto
Journal:  Blood       Date:  1989-07       Impact factor: 22.113

Review 4.  Report of the committee on structural chromosome changes in neoplasia.

Authors:  J M Trent; Y Kaneko; F Mitelman
Journal:  Cytogenet Cell Genet       Date:  1989

5.  Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.

Authors:  G R Sutherland; E Baker; D F Callen; V J Hyland; G Wong; S Clark; S S Jones; L K Eglinton; M F Shannon; A F Lopez
Journal:  Hum Genet       Date:  1988-08       Impact factor: 4.132

6.  Cytokine production by the bladder carcinoma cell line 5637: rapid analysis of mRNA expression levels using a cDNA-PCR procedure.

Authors:  J G Kaashoek; R Mout; J H Falkenburg; R Willemze; W E Fibbe; J E Landegent
Journal:  Lymphokine Cytokine Res       Date:  1991-06

7.  The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4.

Authors:  J Szpirer; C Szpirer; M Rivière; C Houart; M Baumann; G H Fey; V Poli; R Cortese; M Q Islam; G Levan
Journal:  Genomics       Date:  1991-07       Impact factor: 5.736

8.  Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

Authors:  K Yamasaki; T Taga; Y Hirata; H Yawata; Y Kawanishi; B Seed; T Taniguchi; T Hirano; T Kishimoto
Journal:  Science       Date:  1988-08-12       Impact factor: 47.728

9.  Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization.

Authors:  J E Landegent; N Jansen in de Wal; R W Dirks; F Baao; M van der Ploeg
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

10.  Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.

Authors:  T Sugita; T Totsuka; M Saito; K Yamasaki; T Taga; T Hirano; T Kishimoto
Journal:  J Exp Med       Date:  1990-06-01       Impact factor: 14.307
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  7 in total

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Authors:  Chang-Hsun Hsieh; Yi-Jen Hung; Ling-I Wu; Chih-Tsueng He; Chien-Hsing Lee; Fone-Ching Hsiao; Nain-Feng Chu
Journal:  Genet Test Mol Biomarkers       Date:  2012-10-24

3.  Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population.

Authors:  Zhong Chen; Qi Qian; Chengchun Tang; Jiandong Ding; Yi Feng; Genshan Ma
Journal:  Mol Biol Rep       Date:  2012-10-18       Impact factor: 2.316

4.  Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization.

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Journal:  Hum Genet       Date:  1994-01       Impact factor: 4.132

5.  Order of human hematopoietic growth factor and receptor genes on the long arm of chromosome 5, as determined by fluorescence in situ hybridization.

Authors:  P M Kluck; J Wiegant; A K Raap; H Vrolijk; H J Tanke; R Willemze; J E Landegent
Journal:  Ann Hematol       Date:  1993-01       Impact factor: 3.673

6.  Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan.

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Journal:  Lipids Health Dis       Date:  2011-08-12       Impact factor: 3.876

Review 7.  Interleukin‑6 signalling as a valuable cornerstone for molecular medicine (Review).

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  7 in total

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