Literature DB >> 3136546

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

K Yamasaki1, T Taga, Y Hirata, H Yawata, Y Kawanishi, B Seed, T Taniguchi, T Hirano, T Kishimoto.   

Abstract

Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.

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Year:  1988        PMID： 3136546     DOI： 10.1126/science.3136546

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  208 in total

Review 1.  Receptor recognition by gp130 cytokines.

Authors:  J Bravo; J K Heath
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

2.  Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.

Authors:  J N Varghese; R L Moritz; M-Z Lou; A Van Donkelaar; H Ji; N Ivancic; K M Branson; N E Hall; R J Simpson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-02       Impact factor: 11.205

3.  The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.

Authors:  L I Zon; J F Moreau; J W Koo; B Mathey-Prevot; A D D'Andrea
Journal:  Mol Cell Biol       Date:  1992-07       Impact factor: 4.272

Review 4.  Cytokine receptors: structure and signal transduction.

Authors:  B M Foxwell; K Barrett; M Feldmann
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330

5.  Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs.

Authors:  Stephan W Lindemann; Christian C Yost; Melvin M Denis; Thomas M McIntyre; Andrew S Weyrich; Guy A Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-26       Impact factor: 11.205

6.  Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells.

Authors:  M Roth; M Nauck; M Tamm; A P Perruchoud; R Ziesche; L H Block
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

7.  Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression.

Authors:  J Ohara; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

Review 8.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Authors:  P C Heinrich; I Behrmann; G Müller-Newen; F Schaper; L Graeve
Journal:  Biochem J       Date:  1998-09-01       Impact factor: 3.857

9.  The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.

Authors:  D P Ramji; A Vitelli; F Tronche; R Cortese; G Ciliberto
Journal:  Nucleic Acids Res       Date:  1993-01-25       Impact factor: 16.971

10.  Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis.

Authors:  F De Benedetti; M Massa; P Pignatti; S Albani; D Novick; A Martini
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808
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