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Literature DB >> 8417359

The REB1 site is an essential component of a terminator for RNA polymerase I in Saccharomyces cerevisiae.

Abstract

We have identified a terminator for transcription by RNA polymerase I in the genes coding for rRNA of the yeast Saccharomyces cerevisiae. The terminator is located 108 bp downstream of the 3' end of the mature 25S rRNA and shares several characteristics with previously studied polymerase I terminators in the vertebrates. For example, the yeast terminator is orientation dependent, is inhibited by its own sequence, and forms RNA 3' ends 17 +/- 2 bp upstream of an essential protein binding site. The recognition sequence for binding of the previously cloned REB1 protein (Q. Ju, B. E. Morrow, and J. R. Warner, Mol. Cell. Biol. 10:5226-5234, 1990) is an essential component of the terminator. In addition, the efficiency of termination depends upon sequence context extending at least 12 bp upstream of the REB1 site.

Entities: Gene Species

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Year: 1993 PMID： 8417359 PMCID： PMC358943 DOI： 10.1128/mcb.13.1.649-658.1993

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

32 in total

1. Interchangeable RNA polymerase I and II enhancers.

Authors: Y Lorch; N F Lue; R D Kornberg
Journal: Proc Natl Acad Sci U S A Date: 1990-11 Impact factor: 11.205

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Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

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Authors: B McStay; R H Reeder
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

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Journal: J Biol Chem Date: 1977-11-25 Impact factor: 5.157

5. REB1, a yeast DNA-binding protein with many targets, is essential for growth and bears some resemblance to the oncogene myb.

Authors: Q D Ju; B E Morrow; J R Warner
Journal: Mol Cell Biol Date: 1990-10 Impact factor: 4.272

6. Identification of a site required for DNA replication fork blocking activity in the rRNA gene cluster in Saccharomyces cerevisiae.

Authors: T Kobayashi; M Hidaka; M Nishizawa; T Horiuchi
Journal: Mol Gen Genet Date: 1992-06

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Authors: S Y Choe; M C Schultz; R H Reeder
Journal: Nucleic Acids Res Date: 1992-01-25 Impact factor: 16.971

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Authors: M C Schultz; S Y Choe; R H Reeder
Journal: Proc Natl Acad Sci U S A Date: 1991-02-01 Impact factor: 11.205

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Journal: EMBO J Date: 1983 Impact factor: 11.598

10. Unusual transcription termination of the ribosomal RNA genes in Ascaris lumbricoides.

Authors: E Müller; H Neuhaus; H Tobler; F Müller
Journal: EMBO J Date: 1990-09 Impact factor: 11.598

51 in total

1. The transcript release factor PTRF augments ribosomal gene transcription by facilitating reinitiation of RNA polymerase I.

Authors: P Jansa; C Burek; E E Sander; I Grummt
Journal: Nucleic Acids Res Date: 2001-01-15 Impact factor: 16.971

2. A single-stranded DNA-binding protein shared by telomeric repeats, the variant surface glycoprotein transcription promoter and the procyclin transcription terminator of Trypanosoma brucei.

Authors: M Berberof; L Vanhamme; S Alexandre; S Lips; P Tebabi; E Pays
Journal: Nucleic Acids Res Date: 2000-01-15 Impact factor: 16.971

Review 3. Survey and summary: transcription by RNA polymerases I and III.

Authors: M R Paule; R J White
Journal: Nucleic Acids Res Date: 2000-03-15 Impact factor: 16.971

4. Polyadenylation of rRNA- and tRNA-based yeast transcripts cleaved by internal ribozyme activity.

Authors: Katrin Düvel; Ralph Pries; Gerhard H Braus
Journal: Curr Genet Date: 2003-05-14 Impact factor: 3.886

5. Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p.

Authors: Elizabeth M Prescott; Yvonne N Osheim; Hannah S Jones; Claudia M Alen; Judith G Roan; Ronald H Reeder; Ann L Beyer; Nick J Proudfoot
Journal: Proc Natl Acad Sci U S A Date: 2004-04-08 Impact factor: 11.205

6. RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae.

Authors: David A Schneider; Masayasu Nomura
Journal: Proc Natl Acad Sci U S A Date: 2004-10-11 Impact factor: 11.205

7. Yeast nuclear RNA processing.

Authors: Jade Bernstein; Eric A Toth
Journal: World J Biol Chem Date: 2012-01-26

8. Replication fork barriers in the Xenopus rDNA.

Authors: B Wiesendanger; R Lucchini; T Koller; J M Sogo
Journal: Nucleic Acids Res Date: 1994-11-25 Impact factor: 16.971

9. Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I.

Authors: R Evers; I Grummt
Journal: Proc Natl Acad Sci U S A Date: 1995-06-20 Impact factor: 11.205

10. Binding of the termination factor Nsi1 to its cognate DNA site is sufficient to terminate RNA polymerase I transcription in vitro and to induce termination in vivo.

Authors: Philipp Merkl; Jorge Perez-Fernandez; Michael Pilsl; Alarich Reiter; Lydia Williams; Jochen Gerber; Maria Böhm; Rainer Deutzmann; Joachim Griesenbeck; Philipp Milkereit; Herbert Tschochner
Journal: Mol Cell Biol Date: 2014-08-04 Impact factor: 4.272