Literature DB >> 8386393

Reversible binding of nitric oxide by a salivary heme protein from a bloodsucking insect.

J M Ribeiro1, J M Hazzard, R H Nussenzveig, D E Champagne, F A Walker.   

Abstract

The bloodsucking bug Rhodnius prolixus has a salivary vasodilator, previously characterized as a nitrovasodilator, with salivary smooth muscle-relaxing and antiplatelet activity. Rhodnius salivary glands are bright red owing to the abundance of heme proteins. Electron paramagnetic resonance and optical spectroscopic experiments indicated that the salivary vasodilator is a nitrosylheme protein with an Fe(III) heme that binds nitric oxide (NO) reversibly. Dilution of the protein in neutral pH promoted NO release. This protein thus appears to be the NO carrier that helps R. prolixus to feed on blood.

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Year:  1993        PMID： 8386393     DOI： 10.1126/science.8386393

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  64 in total

1.  NO binding kinetics in myoglobin investigated by picosecond Fe K-edge absorption spectroscopy.

Authors:  Mahsa Silatani; Frederico A Lima; Thomas J Penfold; Jochen Rittmann; Marco E Reinhard; Hannelore M Rittmann-Frank; Camelia Borca; Daniel Grolimund; Christopher J Milne; Majed Chergui
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-05       Impact factor: 11.205

Review 2.  The role of salivary lipocalins in blood feeding by Rhodnius prolixus.

Authors:  John F Andersen; Nanda P Gudderra; Ivo M B Francischetti; José M C Ribeiro
Journal:  Arch Insect Biochem Physiol       Date:  2005-02       Impact factor: 1.698

3.  Salivary apyrases of Triatoma infestans are assembled into homo-oligomers.

Authors:  Eric Faudry; Jaime M Santana; Christine Ebel; Thierry Vernet; Antonio R L Teixeira
Journal:  Biochem J       Date:  2006-06-15       Impact factor: 3.857

4.  Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.

Authors:  Robert E Berry; Maxim N Shokhirev; Arthur Y W Ho; Fei Yang; Tatiana K Shokhireva; Hongjun Zhang; Andrzej Weichsel; William R Montfort; F Ann Walker
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419

5.  Study of the Salivary Glands in Triatominae (Hemiptera, Reduviidae, Triatominae): Their Color and Application to the Chagas Disease Vector Evolution.

Authors:  Jader de Oliveira; Amanda Ravazi; Eder Dos Santos Souza; Felipe Ferraz Figueiredo Moreira; Cleber Galvão; João Aristeu da Rosa; Kaio Cesar Chaboli Alevi
Journal:  Am J Trop Med Hyg       Date:  2017-07-19       Impact factor: 2.345

6.  Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: stability, structure, and dynamics of axial ligand complexes.

Authors:  Tatjana Kh Shokhireva; Robert E Berry; Elizabeth Uno; Celia A Balfour; Hongjun Zhang; F Ann Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-17       Impact factor: 11.205

7.  Electron spin density on the axial His ligand of high-spin and low-spin nitrophorin 2 probed by heteronuclear NMR spectroscopy.

Authors:  Luciano A Abriata; María-Eugenia Zaballa; Robert E Berry; Fei Yang; Hongjun Zhang; F Ann Walker; Alejandro J Vila
Journal:  Inorg Chem       Date:  2013-01-17       Impact factor: 5.165

8.  High affinity histamine-binding and antihistaminic activity of the salivary nitric oxide-carrying heme protein (nitrophorin) of Rhodnius prolixus.

Authors:  J M Ribeiro; F A Walker
Journal:  J Exp Med       Date:  1994-12-01       Impact factor: 14.307

9.  Assignment of the ferriheme resonances of high- and low-spin forms of the symmetrical hemin-reconstituted nitrophorins 1-4 by 1H and 13C NMR spectroscopy: the dynamics of heme ruffling deformations.

Authors:  Tatiana K Shokhireva; Nikolai V Shokhirev; Robert E Berry; Hongjun Zhang; F Ann Walker
Journal:  J Biol Inorg Chem       Date:  2008-05-06       Impact factor: 3.358

10.  Purification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood-sucking bug Rhodnius prolixus.

Authors:  J M Ribeiro; M Schneider; J A Guimarães
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857
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