Literature DB >> 8371982

The fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth.

S K Alahari1, H Schmidt, N F Käufer.   

Abstract

Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III.

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Year:  1993        PMID： 8371982      PMCID： PMC310008          DOI： 10.1093/nar/21.17.4079

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  37 in total

Review 1.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

Authors:  S K Hanks; A M Quinn; T Hunter
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

Review 2.  Splicing of messenger RNA precursors.

Authors:  R A Padgett; P J Grabowski; M M Konarska; S Seiler; P A Sharp
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

3.  The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction.

Authors:  E Brody; J Abelson
Journal:  Science       Date:  1985-05-24       Impact factor: 47.728

4.  Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing.

Authors:  J Tazi; U Kornstädt; F Rossi; P Jeanteur; G Cathala; C Brunel; R Lührmann
Journal:  Nature       Date:  1993-05-20       Impact factor: 49.962

5.  The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases.

Authors:  H Ohkura; N Kinoshita; S Miyatani; T Toda; M Yanagida
Journal:  Cell       Date:  1989-06-16       Impact factor: 41.582

6.  Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control.

Authors:  R Booher; D Beach
Journal:  Cell       Date:  1989-06-16       Impact factor: 41.582

7.  Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker.

Authors:  C Grimm; J Kohli; J Murray; K Maundrell
Journal:  Mol Gen Genet       Date:  1988-12

8.  Introduction of functional artificial introns into the naturally intronless ura4 gene of Schizosaccharomyces pombe.

Authors:  K B Gatermann; A Hoffmann; G H Rosenberg; N F Käufer
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

9.  Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence.

Authors:  N F Käufer; V Simanis; P Nurse
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962

10.  Pre-mRNA splicing mutants of Schizosaccharomyces pombe.

Authors:  J Potashkin; R Li; D Frendewey
Journal:  EMBO J       Date:  1989-02       Impact factor: 11.598
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  25 in total

1.  Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.

Authors:  W Schwelnus; K Richert; F Opitz; T Gross; Y Habara; T Tani; N F Käufer
Journal:  EMBO Rep       Date:  2001-01       Impact factor: 8.807

2.  Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe.

Authors:  Y Habara; S Urushiyama; T Shibuya; Y Ohshima; T Tani
Journal:  RNA       Date:  2001-05       Impact factor: 4.942

Review 3.  Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals.

Authors:  N F Käufer; J Potashkin
Journal:  Nucleic Acids Res       Date:  2000-08-15       Impact factor: 16.971

4.  spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p.

Authors:  H Schmidt; K Richert; R A Drakas; N F Käufer
Journal:  Genetics       Date:  1999-11       Impact factor: 4.562

5.  Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue.

Authors:  T Gross; M Lützelberger; H Weigmann; A Klingenhoff; S Shenoy; N F Käufer
Journal:  Nucleic Acids Res       Date:  1997-03-01       Impact factor: 16.971

Review 6.  Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.

Authors:  Claudia A Bottner; Henning Schmidt; Sven Vogel; Melanie Michele; Norbert F Käufer
Journal:  Curr Genet       Date:  2005-10-12       Impact factor: 3.886

7.  Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.

Authors:  Qiang Gao; Ingrid Mechin; Nayantara Kothari; Zhuyan Guo; Gejing Deng; Kimberly Haas; Jessica McManus; Dietmar Hoffmann; Anlai Wang; Dmitri Wiederschain; Jennifer Rocnik; Werngard Czechtizky; Xin Chen; Larry McLean; Heike Arlt; David Harper; Feng Liu; Tahir Majid; Vinod Patel; Christoph Lengauer; Carlos Garcia-Echeverria; Bailin Zhang; Hong Cheng; Marion Dorsch; Shih-Min A Huang
Journal:  J Biol Chem       Date:  2013-09-03       Impact factor: 5.157

Review 8.  Pre-mRNA splicing in Schizosaccharomyces pombe: regulatory role of a kinase conserved from fission yeast to mammals.

Authors:  Andreas N Kuhn; Norbert F Käufer
Journal:  Curr Genet       Date:  2002-12-13       Impact factor: 3.886

9.  Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2.

Authors:  Erin M Bennett; Andrew M L Lever; Jane F Allen
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

10.  Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.

Authors:  Graham Dellaire; Evgeny M Makarov; Jeff J M Cowger; Dasa Longman; Heidi G E Sutherland; Reinhard Lührmann; Joseph Torchia; Wendy A Bickmore
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272
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