Literature DB >> 8333566

Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity.

M T Makler1, J M Ries, J A Williams, J E Bancroft, R C Piper, B L Gibbins, D J Hinrichs.   

Abstract

This report compares the use of the lactate dehydrogenase (pLDH) assay with 3H-hypoxanthine incorporation and Giemsa microscopy for the evaluation of anti-malaria drug inhibition of the growth of P. falciparum in vitro. The inhibition profiles and IC50 determinations of the pLDH assay were directly comparable to those determined by the radioactive uptake and microscopic methods. Furthermore, the pLDH culture sensitivity assay is reproducible, easily interpreted, rapid and inexpensive to perform, suggesting field applicability.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8333566     DOI： 10.4269/ajtmh.1993.48.739

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  166 in total

1.  Histidine-rich protein II: a novel approach to malaria drug sensitivity testing.

Authors:  Harald Noedl; Walther H Wernsdorfer; Robert Scott Miller; Chansuda Wongsrichanalai
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

2.  Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms.

Authors:  Abiodun Falodun; Vincent Imieje; Osayewenre Erharuyi; Joy Ahomafor; Melissa R Jacob; Shabana I Khan; Mark T Hamann
Journal:  Afr J Tradit Complement Altern Med       Date:  2014-06-04

3.  A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.

Authors:  William Guerrant; Sandra C Mwakwari; Po C Chen; Shabana I Khan; Babu L Tekwani; Adegboyega K Oyelere
Journal:  ChemMedChem       Date:  2010-08-02       Impact factor: 3.466

Review 4.  Microfluidic approaches to malaria detection.

Authors:  Peter Gascoyne; Jutamaad Satayavivad; Mathuros Ruchirawat
Journal:  Acta Trop       Date:  2004-02       Impact factor: 3.112

Review 5.  History, dynamics, and public health importance of malaria parasite resistance.

Authors:  Ambrose O Talisuna; Peter Bloland; Umberto D'Alessandro
Journal:  Clin Microbiol Rev       Date:  2004-01       Impact factor: 26.132

6.  Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors.

Authors:  Antonello Mai; Ilaria Cerbara; Sergio Valente; Silvio Massa; Larry A Walker; Babu L Tekwani
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

7.  Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.

Authors:  Sandra C Mwakwari; William Guerrant; Vishal Patil; Shabana I Khan; Babu L Tekwani; Zachary A Gurard-Levin; Milan Mrksich; Adegboyega K Oyelere
Journal:  J Med Chem       Date:  2010-08-26       Impact factor: 7.446

8.  Poly(I:C) adjuvant strongly enhances parasite-inhibitory antibodies and Th1 response against Plasmodium falciparum merozoite surface protein-1 (42-kDa fragment) in BALB/c mice.

Authors:  Akram Abouie Mehrizi; Niloufar Rezvani; Sedigheh Zakeri; Atefeh Gholami; Laleh Babaeekhou
Journal:  Med Microbiol Immunol       Date:  2018-02-03       Impact factor: 3.402

9.  Reversal of chloroquine resistance in Plasmodium falciparum using combinations of chemosensitizers.

Authors:  D A van Schalkwyk; J C Walden; P J Smith
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

10.  Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.

Authors:  Eithne Cunningham; Marcin Drag; Pawel Kafarski; Angus Bell
Journal:  Antimicrob Agents Chemother       Date:  2008-05-05       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.