Abiodun Falodun1, Vincent Imieje2, Osayewenre Erharuyi2, Joy Ahomafor3, Melissa R Jacob4, Shabana I Khan4, Mark T Hamann5. 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria ; Department of Pharmacognosy, School of Pharmacy, University, University of Mississippi, MS 38655, USA. 2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria ; Institute of Organic Chemistry, University of Restock, 18509, Restock, Germany. 3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria. 4. Center for for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 38677, USA. 5. Department of Pharmacognosy, School of Pharmacy, University, University of Mississippi, MS 38655, USA.
Abstract
BACKGROUND: A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities. MATERIALS AND METHODS: Extracts obtained from parts of Persea americana, Jatropha podagrica and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity. RESULT: The methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC50 values of 6.3 and 6.0 µg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans IC50 less than 8 and 8.211 µg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillin-resistant Staphylococcus aureus (MRSA) with an IC50 value of 8.7 µg/mL. CONCLUSION: The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.
BACKGROUND: A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities. MATERIALS AND METHODS: Extracts obtained from parts of Persea americana, Jatropha podagrica and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity. RESULT: The methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC50 values of 6.3 and 6.0 µg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans IC50 less than 8 and 8.211 µg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillin-resistant Staphylococcus aureus (MRSA) with an IC50 value of 8.7 µg/mL. CONCLUSION: The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.
Authors: S G Franzblau; R S Witzig; J C McLaughlin; P Torres; G Madico; A Hernandez; M T Degnan; M B Cook; V K Quenzer; R M Ferguson; R H Gilman Journal: J Clin Microbiol Date: 1998-02 Impact factor: 5.948
Authors: M T Makler; J M Ries; J A Williams; J E Bancroft; R C Piper; B L Gibbins; D J Hinrichs Journal: Am J Trop Med Hyg Date: 1993-06 Impact factor: 2.345