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Literature DB >> 8321194

Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

Abstract

The MSN2 gene was selected as a multicopy suppressor in a temperature-sensitive SNF1 protein kinase mutant of Saccharomyces cerevisiae. MSN2 encodes a Cys2His2 zinc finger protein related to the yeast MIG1 repressor and to mammalian early growth response and Wilms' tumor zinc finger proteins. Deletion of MSN2 caused no phenotype. A second similar zinc finger gene, MSN4, was isolated, and deletion of both genes caused phenotypic defects related to carbon utilization. Overexpression of the zinc finger regions was deleterious to growth. LexA-MSN2 and LexA-MSN4 fusion proteins functioned as strong transcriptional activators when bound to DNA. Functional roles of this zinc finger protein family are discussed.

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Year: 1993 PMID： 8321194 PMCID： PMC359918 DOI： 10.1128/mcb.13.7.3872-3881.1993

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

54 in total

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6. A novel genetic system to detect protein-protein interactions.

Authors: S Fields; O Song
Journal: Nature Date: 1989-07-20 Impact factor: 49.962

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Journal: Proc Natl Acad Sci U S A Date: 1989-11 Impact factor: 11.205

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Authors: L J Joseph; M M Le Beau; G A Jamieson; S Acharya; T B Shows; J D Rowley; V P Sukhatme
Journal: Proc Natl Acad Sci U S A Date: 1988-10 Impact factor: 11.205

9. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

Authors: B A Christy; L F Lau; D Nathans
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

10. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

Authors: R S Sikorski; P Hieter
Journal: Genetics Date: 1989-05 Impact factor: 4.562

101 in total

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7. Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1.

Authors: I Pedruzzi; N Bürckert; P Egger; C De Virgilio
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