Literature DB >> 3141919

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

B A Christy1, L F Lau, D Nathans.   

Abstract

We have recently identified by cDNA cloning a set of genes that are rapidly activated in mouse 3T3 cells by serum or purified growth factors. Here we report that the cDNA (clone 268) derived from one of these immediate early genes (zif/268) encodes a protein with three tandem "zinc finger" sequences typical of a class of eukaryotic transcription factors. The mRNA of zif/268 is present in many organs and tissues of the mouse and is especially abundant in the brain and thymus tissue. The 5' genomic flanking sequence of zif/268 has sequences related to binding sites for known regulatory proteins, including four sequences that resemble the core of the serum response elements (SREs) upstream of the c-fos and actin genes. The SRE-like sequences could be responsible for the coordinate activation of zif/268 and fos after serum stimulation of 3T3 cells.

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Year:  1988        PMID： 3141919      PMCID： PMC282296          DOI： 10.1073/pnas.85.21.7857

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  46 in total

1.  Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences.

Authors:  R Treisman
Journal:  Cell       Date:  1985-10       Impact factor: 41.582

2.  Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.

Authors:  J Pelletier; N Sonenberg
Journal:  Cell       Date:  1985-03       Impact factor: 41.582

3.  Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Authors:  L F Lau; D Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

4.  Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

Authors:  M E Greenberg; Z Siegfried; E B Ziff
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272

5.  Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.

Authors:  M E Greenberg; E B Ziff
Journal:  Nature       Date:  1984 Oct 4-10       Impact factor: 49.962

6.  Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 3' end formation.

Authors:  M Wickens; P Stephenson
Journal:  Science       Date:  1984-11-30       Impact factor: 47.728

7.  Molecular cloning of gene sequences regulated by platelet-derived growth factor.

Authors:  B H Cochran; A C Reffel; C D Stiles
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

8.  Convulsant-induced increase in transcription factor messenger RNAs in rat brain.

Authors:  D W Saffen; A J Cole; P F Worley; B A Christy; K Ryder; J M Baraban
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

9.  Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

Authors:  L F Lau; D Nathans
Journal:  EMBO J       Date:  1985-12-01       Impact factor: 11.598

10.  Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

Authors:  J Miller; A D McLachlan; A Klug
Journal:  EMBO J       Date:  1985-06       Impact factor: 11.598
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  175 in total

1.  Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences.

Authors:  B S Wang; C O Pabo
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

Review 2.  The biology of the mammalian Krüppel-like family of transcription factors.

Authors:  D T Dang; J Pevsner; V W Yang
Journal:  Int J Biochem Cell Biol       Date:  2000 Nov-Dec       Impact factor: 5.085

3.  Circular permutation and receptor insertion within green fluorescent proteins.

Authors:  G S Baird; D A Zacharias; R Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

4.  COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site.

Authors:  C Pipaón; S Y Tsai; M J Tsai
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

5.  Post-transcriptional regulation of zenk expression associated with zebra finch vocal development.

Authors:  O Whitney; K Soderstrom; F Johnson
Journal:  Brain Res Mol Brain Res       Date:  2000-09-15

6.  Stat1-independent regulation of gene expression in response to IFN-gamma.

Authors:  C V Ramana; M P Gil; Y Han; R M Ransohoff; R D Schreiber; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

7.  Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells.

Authors:  M Stula; H D Orzechowski; S Gschwend; R Vetter; R von Harsdorf; R Dietz; M Paul
Journal:  Mol Cell Biochem       Date:  2000-07       Impact factor: 3.396

8.  A putative transcription factor with seven zinc-finger motifs identified in the developing suprachiasmatic nucleus by the differential display PCR method.

Authors:  Y Maebayashi; Y Shigeyoshi; T Takumi; H Okamura
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

9.  Control of vascular smooth-muscle cell growth by macrophage-colony-stimulating factor.

Authors:  T Herembert; J Gogusev; D L Zhu; T B Drueke; P Marche
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

10.  DNA binding site of the growth factor-inducible protein Zif268.

Authors:  B Christy; D Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205
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