Literature DB >> 830640

Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.

S Lederberg, R L Gourse, D L Sackett.   

Abstract

Mutants of Schizosaccharomyces pombe, which were resistant to concentrations of colcemid inhibitory to the wild-type parent, were not diminished in their permeability to colcemid or colchicine. They also did not modify colcemid to a detectable derivative or to a product that was incapable of binding to brain tubulin. The resistance of these mutants was therefore via mechanisms different from those of permeability and detoxification known for animal cells.

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Year:  1977        PMID： 830640      PMCID： PMC234915          DOI： 10.1128/jb.129.1.198-201.1977

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.

Authors:  H Umezawa; S Takasawa; M Okanishi; R Utahara
Journal:  J Antibiot (Tokyo)       Date:  1968-01       Impact factor: 2.649

2.  Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

Authors:  S Okamoto; Y Suzuki
Journal:  Nature       Date:  1965-12-25       Impact factor: 49.962

3.  Metabolic transformation of colchicine, II. The metabolism of colchicine by mammalian liver microsomes.

Authors:  M Schönharting; G Mende; G Siebert
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1974-11

4.  Reduced permeability in CHO cells as a mechanism of resistance to colchicine.

Authors:  V Ling; L H Thompson
Journal:  J Cell Physiol       Date:  1974-02       Impact factor: 6.384

5.  The biochemical events of mitosis. I. Synthesis and properties of colchicine labeled with tritium in its acetyl moiety.

Authors:  L Wilson; M Friedkin
Journal:  Biochemistry       Date:  1966-07       Impact factor: 3.162

6.  Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.

Authors:  M Grenson; M Mousset; J M Wiame; J Bechet
Journal:  Biochim Biophys Acta       Date:  1966-10-31

7.  Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants.

Authors:  S Lederberg; G Stetten
Journal:  Science       Date:  1970-04-24       Impact factor: 47.728

8.  AMINO ACID ACCUMULATION IN ETHIONINE-RESISTANT SACCHAROMYCES CEREVISIAE.

Authors:  W A SORSOLI; K D SPENCE; L W PARKS
Journal:  J Bacteriol       Date:  1964-07       Impact factor: 3.490

9.  Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae.

Authors:  J E Haber; J G Peloquin; H O Halvorson; G G Borisy
Journal:  J Cell Biol       Date:  1972-11       Impact factor: 10.539

10.  The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein.

Authors:  G G Borisy; E W Taylor
Journal:  J Cell Biol       Date:  1967-08       Impact factor: 10.539
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  1 in total

1.  Genetic analysis of resistant mutants to antimitotic benzimidazole compounds in Schizosaccharomyces pombe.

Authors:  M Yamamoto
Journal:  Mol Gen Genet       Date:  1980
  1 in total

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