Literature DB >> 7003311

Genetic analysis of resistant mutants to antimitotic benzimidazole compounds in Schizosaccharomyces pombe.

M Yamamoto.   

Abstract

Mutants resistant to the antimitotic compounds thiabendazole and methyl-2-benzimidazole-carbamate were isolated and analyzed genetically in the fission yeast. Schizosaccharomyces pombe. They comprised three groups in terms of genetic linkage. Mutants in one linkage group (ben1) differed phenotypically from those in the other two (ben2 and ben3). The former were resistant to the compounds at any physiological temperature tested, whereas the latter exhibited temperature dependent resistance. Through tetrad analysis, ben1 was mapped at the rightmost part of chromosome II, and ben2 was mapped near the centromere of the same chromosome. Haploidization experiments revealed the location of ben3 on chromosome II. By analogy with Aspergillus nidulans, it is suggested that one of these ben genes may code for tubulin.

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Year:  1980        PMID： 7003311     DOI： 10.1007/bf00267375

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  14 in total

1.  Genetic control of cell size at cell division in yeast.

Authors:  P Nurse
Journal:  Nature       Date:  1975-08-14       Impact factor: 49.962

2.  Biochemical Mutants in the Smut Fungus Ustilago Maydis.

Authors:  D D Perkins
Journal:  Genetics       Date:  1949-09       Impact factor: 4.562

3.  Benlate-induced instability of Aspergillus diploids.

Authors:  A C Hastie
Journal:  Nature       Date:  1970-05-23       Impact factor: 49.962

4.  Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Authors:  J Kohli; H Hottinger; P Munz; A Strauss; P Thuriaux
Journal:  Genetics       Date:  1977-11       Impact factor: 4.562

5.  Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.

Authors:  S Lederberg; R L Gourse; D L Sackett
Journal:  J Bacteriol       Date:  1977-01       Impact factor: 3.490

6.  Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe.

Authors:  M Minet; P Nurse; P Thuriaux; J M Mitchison
Journal:  J Bacteriol       Date:  1979-01       Impact factor: 3.490

7.  Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants.

Authors:  S Lederberg; G Stetten
Journal:  Science       Date:  1970-04-24       Impact factor: 47.728

8.  Mutants altered in the control co-ordinating cell division with cell growth in the fission yeast Schizosaccharomyces pombe.

Authors:  P Thuriaux; P Nurse; B Carter
Journal:  Mol Gen Genet       Date:  1978-05-03

9.  Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans.

Authors:  L C Davidse; W Flach
Journal:  J Cell Biol       Date:  1977-01       Impact factor: 10.539

10.  Mitosis in the fission yeast Schizosaccharomyces pombe: a comparative study with light and electron microscopy.

Authors:  E K McCully; C F Robinow
Journal:  J Cell Sci       Date:  1971-09       Impact factor: 5.285
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  18 in total

1.  Novel mad2 alleles isolated in a Schizosaccharomyces pombe gamma-tubulin mutant are defective in metaphase arrest activity, but remain functional for chromosome stability in unperturbed mitosis.

Authors:  Yoshie Tange; Osami Niwa
Journal:  Genetics       Date:  2007-02-04       Impact factor: 4.562

2.  A revised chromosome map of the fission yeast Schizosaccharomyces pombe.

Authors:  A Gygax; P Thuriaux
Journal:  Curr Genet       Date:  1984-02       Impact factor: 3.886

3.  A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years.

Authors:  Peter A Fantes; Charles S Hoffman
Journal:  Genetics       Date:  2016-06       Impact factor: 4.562

4.  Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.

Authors:  P Radcliffe; D Hirata; D Childs; L Vardy; T Toda
Journal:  Mol Biol Cell       Date:  1998-07       Impact factor: 4.138

5.  Pap1 + confers microtubule damage resistance to mut2a, an extragenic suppressor of the rad26:4A allele in S. pombe.

Authors:  Shivangi Paliwal; Robert Wheeler; Tom D Wolkow
Journal:  Mol Biol Res Commun       Date:  2018-09

6.  Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae.

Authors:  P J Schatz; F Solomon; D Botstein
Journal:  Genetics       Date:  1988-11       Impact factor: 4.562

7.  Differential expressions of essential and nonessential alpha-tubulin genes in Schizosaccharomyces pombe.

Authors:  Y Adachi; T Toda; O Niwa; M Yanagida
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

8.  Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.

Authors:  P J Schatz; F Solomon; D Botstein
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

Review 9.  Drug resistance in human pathogenic fungi.

Authors:  K Iwata
Journal:  Eur J Epidemiol       Date:  1992-05       Impact factor: 8.082

Review 10.  Gene database for the fission yeast Schizosaccharomyces pombe.

Authors:  G G Lennon; H Lehrach
Journal:  Curr Genet       Date:  1992-01       Impact factor: 3.886
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