Literature DB >> 5436084

Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants.

S Lederberg, G Stetten.   

Abstract

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continiues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

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Year:  1970        PMID： 5436084     DOI： 10.1126/science.168.3930.485

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Protomyces inundatus, a yeast which is sensitive to griseofulvin.

Authors:  A P Trinci; K Gull
Journal:  Arch Mikrobiol       Date:  1973-12-31

2.  Altered sensitivity to cholchicine and PHA in human cultured cells.

Authors:  Y Chamla; M Roumy; M Lassègues; J Battin
Journal:  Hum Genet       Date:  1980-02       Impact factor: 4.132

3.  Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.

Authors:  S Lederberg; R L Gourse; D L Sackett
Journal:  J Bacteriol       Date:  1977-01       Impact factor: 3.490

4.  Genetic analysis of resistant mutants to antimitotic benzimidazole compounds in Schizosaccharomyces pombe.

Authors:  M Yamamoto
Journal:  Mol Gen Genet       Date:  1980

5.  Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistant mutants.

Authors:  M Flavin; C Slaughter
Journal:  J Bacteriol       Date:  1974-04       Impact factor: 3.490

6.  Isolation of Chinese hamster ovary cell mutants requiring the continuous presence of taxol for cell division.

Authors:  F R Cabral
Journal:  J Cell Biol       Date:  1983-07       Impact factor: 10.539

7.  Colcemid sensitivity of fission yeast. II. Sensitivity of stages of the cell cycle.

Authors:  G Stetten; S Lederberg
Journal:  J Cell Biol       Date:  1973-01       Impact factor: 10.539

8.  Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae.

Authors:  J E Haber; J G Peloquin; H O Halvorson; G G Borisy
Journal:  J Cell Biol       Date:  1972-11       Impact factor: 10.539

9.  Taxol-dependent mutants of Chinese hamster ovary cells with alterations in alpha- and beta-tubulin.

Authors:  M J Schibler; F Cabral
Journal:  J Cell Biol       Date:  1986-04       Impact factor: 10.539
  9 in total

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