Literature DB >> 8234269

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin.

M C Kibbey1, M Jucker, B S Weeks, R L Neve, W E Van Nostrand, H K Kleinman.   

Abstract

We previously characterized a 110-kDa membrane-associated laminin-binding protein (LBP110) from brain which binds the laminin A chain -Ile-Lys-Val-Ala-Val-(IKVAV) site and increases in injury. Here we demonstrate that antisera directed against different epitopes of beta-amyloid precursor protein (APP) recognize LBP110 and that APP is recognized by LBP110 antiserum. APP specifically binds IKVAV and not another biologically active laminin-derived peptide containing the amino acid sequence -Tyr-Ile-Gly-Ser-Arg-. PC-12 cells transfected with antisense APP RNA produce less APP and LBP110, and they form fewer processes when cultured on either laminin or the IKVAV peptide. Thus, LBP110 is a member of the APP family and a function for APP in neurite outgrowth is now defined.

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Year:  1993        PMID： 8234269      PMCID： PMC47731          DOI： 10.1073/pnas.90.21.10150

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

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2.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

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3.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Authors:  G G Glenner; C W Wong
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5.  Neural crest-derived cells isolated from the gut by immunoselection develop neuronal and glial phenotypes when cultured on laminin.

Authors:  H D Pomeranz; T P Rothman; A Chalazonitis; V M Tennyson; M D Gershon
Journal:  Dev Biol       Date:  1993-04       Impact factor: 3.582

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Authors:  A Baron-Van Evercooren; H K Kleinman; S Ohno; P Marangos; J P Schwartz; M E Dubois-Dalcq
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7.  Localization of a laminin-binding protein in brain.

Authors:  M Jucker; L C Walker; M C Kibbey; H K Kleinman; D K Ingram
Journal:  Neuroscience       Date:  1993-10       Impact factor: 3.590

8.  Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

Authors:  M R Palmert; T E Golde; M L Cohen; D M Kovacs; R E Tanzi; J F Gusella; M F Usiak; L H Younkin; S G Younkin
Journal:  Science       Date:  1988-08-26       Impact factor: 47.728

9.  The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.

Authors:  D Edgar; R Timpl; H Thoenen
Journal:  EMBO J       Date:  1984-07       Impact factor: 11.598

10.  Do neurons in the vertebrate CNS migrate on laminin?

Authors:  P Liesi
Journal:  EMBO J       Date:  1985-05       Impact factor: 11.598
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  44 in total

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Review 9.  The role of glycoproteins in neural development function, and disease.

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10.  Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.

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