Literature DB >> 6375662

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

G G Glenner, C W Wong.   

Abstract

A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography. Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far. This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.

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Year:  1984        PMID： 6375662     DOI： 10.1016/s0006-291x(84)80190-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  1234 in total

Review 1.  Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.

Authors:  M Goedert
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

2.  CADASIL: Notch signaling defect or protein accumulation problem?

Authors:  N B Spinner
Journal:  J Clin Invest       Date:  2000-03       Impact factor: 14.808

Review 3.  Genetic risk factors in Alzheimer's disease.

Authors:  L Tilley; K Morgan; N Kalsheker
Journal:  Mol Pathol       Date:  1998-12

4.  Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.

Authors:  S F Lichtenthaler; R Wang; H Grimm; S N Uljon; C L Masters; K Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

Review 5.  Amyloidosis.

Authors:  M F Khan; R H Falk
Journal:  Postgrad Med J       Date:  2001-11       Impact factor: 2.401

6.  Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide.

Authors:  P S Ajmani; W Wang; F Tang; M A King; E M Meyer; J A Hughes
Journal:  Neurochem Res       Date:  2001-03       Impact factor: 3.996

7.  An atomic model for the pleated beta-sheet structure of Abeta amyloid protofilaments.

Authors:  L Li; T A Darden; L Bartolotti; D Kominos; L G Pedersen
Journal:  Biophys J       Date:  1999-06       Impact factor: 4.033

8.  A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.

Authors:  Aneta T Petkova; Yoshitaka Ishii; John J Balbach; Oleg N Antzutkin; Richard D Leapman; Frank Delaglio; Robert Tycko
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-12       Impact factor: 11.205

9.  Cell surface expression of the Alzheimer disease-related presenilin proteins.

Authors:  N N Dewji; S J Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

10.  A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro.

Authors:  Benjamin J Alper; Walter K Schmidt
Journal:  J Neurosci Methods       Date:  2008-11-21       Impact factor: 2.390
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