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Literature DB >> 16252002

The amyloid-beta precursor protein: integrating structure with biological function.

Constanze Reinhard¹, Sébastien S Hébert, Bart De Strooper.

Abstract

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

Entities: Disease Gene

Mesh：

Substances：

Year: 2005 PMID： 16252002 PMCID： PMC1356301 DOI： 10.1038/sj.emboj.7600860

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

116 in total

1. Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors.

Authors: T A Ramelot; L N Gentile; L K Nicholson
Journal: Biochemistry Date: 2000-03-14 Impact factor: 3.162

2. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.

Authors: A Kamal; A Almenar-Queralt; J F LeBlanc; E A Roberts; L S Goldstein
Journal: Nature Date: 2001-12-06 Impact factor: 49.962

3. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch.

Authors: Y Gu; H Misonou; T Sato; N Dohmae; K Takio; Y Ihara
Journal: J Biol Chem Date: 2001-08-01 Impact factor: 5.157

Review 4. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.

Authors: Frank M LaFerla
Journal: Nat Rev Neurosci Date: 2002-11 Impact factor: 34.870

5. The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

Authors: Leigh D Plant; John P Boyle; Ian F Smith; Chris Peers; Hugh A Pearson
Journal: J Neurosci Date: 2003-07-02 Impact factor: 6.167

Review 6. Caspase-mediated degeneration in Alzheimer's disease.

Authors: David H Cribbs; Wayne W Poon; Robert A Rissman; Mathew Blurton-Jones
Journal: Am J Pathol Date: 2004-08 Impact factor: 4.307

7. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

Authors: Matthew R Hass; Bruce A Yankner
Journal: J Biol Chem Date: 2005-08-15 Impact factor: 5.157

Review 8. Metals and amyloid-beta in Alzheimer's disease.

Authors: Christa J Maynard; Ashley I Bush; Colin L Masters; Roberto Cappai; Qiao-Xin Li
Journal: Int J Exp Pathol Date: 2005-06 Impact factor: 1.925

Review 9. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory.

Authors: Paul R Turner; Kate O'Connor; Warren P Tate; Wickliffe C Abraham
Journal: Prog Neurobiol Date: 2003-05 Impact factor: 11.685

10. JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65.

Authors: Meir H Scheinfeld; Shuji Matsuda; Luciano D'Adamio
Journal: Proc Natl Acad Sci U S A Date: 2003-01-31 Impact factor: 11.205

83 in total

1. Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo.

Authors: Peter Jedlicka; Mirka Owen; Matej Vnencak; Jakob-A Tschäpe; Meike Hick; Ulrike C Müller; Thomas Deller
Journal: Exp Brain Res Date: 2011-11-11 Impact factor: 1.972

Review 2. Proteomic analysis of the presynaptic active zone.

Authors: W Volknandt; M Karas
Journal: Exp Brain Res Date: 2012-02-22 Impact factor: 1.972

Review 3. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

Authors: Bart De Strooper; Takeshi Iwatsubo; Michael S Wolfe
Journal: Cold Spring Harb Perspect Med Date: 2012-01 Impact factor: 6.915

4. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.

Authors: Sébastien S Hébert; Lutgarde Serneels; Alexandra Tolia; Katleen Craessaerts; Carmen Derks; Mikhail A Filippov; Ulrike Müller; Bart De Strooper
Journal: EMBO Rep Date: 2006-05-19 Impact factor: 8.807

5. The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study.

Authors: Nikolaos G Sgourakis; Yilin Yan; Scott A McCallum; Chunyu Wang; Angel E Garcia
Journal: J Mol Biol Date: 2007-03-07 Impact factor: 5.469

6. Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks.

Authors: Maria Stante; Giuseppina Minopoli; Fabiana Passaro; Maddalena Raia; Luigi Del Vecchio; Tommaso Russo
Journal: Proc Natl Acad Sci U S A Date: 2009-03-12 Impact factor: 11.205

Review 7. A TAG on to the neurogenic functions of APP.

Authors: Quan-Hong Ma; Dominique Bagnard; Zhi-Cheng Xiao; Gavin S Dawe
Journal: Cell Adh Migr Date: 2008-01-25 Impact factor: 3.405

Review 8. PPARα Between Aspirin and Plaque Clearance.

Authors: Sujyoti Chandra; Avik Roy; Dhruv R Patel; Kalipada Pahan
Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472

9. Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.

Authors: Gennady A Buznikov; Lyudmila A Nikitina; Frederic J Seidler; Theodore A Slotkin; Vladimir V Bezuglov; Ivan Milosević; Lidija Lazarević; Ljubica Rogac; Sabera Ruzdijić; Ljubisa M Rakić
Journal: Neurotoxicol Teratol Date: 2008-05-16 Impact factor: 3.763

10. The structures of the E22Δ mutant-type amyloid-β alloforms and the impact of E22Δ mutation on the structures of the wild-type amyloid-β alloforms.

Authors: Orkid Coskuner; Olivia Wise-Scira; George Perry; Taizo Kitahara
Journal: ACS Chem Neurosci Date: 2012-12-18 Impact factor: 4.418