BACKGROUND AND OBJECTIVES: Adolescent girls may have isolated asymptomatic urethral Chlamydia trachomatis infection. GOAL OF THIS STUDY: To determine if a single direct fluorescent antibody (DFA) slide can detect as many urethral and cervical infections as the use of separate slides and to determine if isolated urethral infection occurs. STUDY DESIGN: During pelvic examinations upon admission, DFA slides were prepared from the cervix, from the urethra, and with cells from both sites. RESULTS: Of 125 girls, 17 had C. trachomatis infection: 4 in the urethra only (24%), 5 in the cervical sample only (31%), 5 in both sites (31%), 3 had positive results only on the combined slide, and 1 had a positive result on the cervical slide and an inadequate urethral slide. CONCLUSION: Isolated urethral C. trachomatis infection occurs frequently, and sampling both sites as opposed to sampling the cervix alone increases the number of cases found by 24% (P < 0.002). Using a single slide to detect infection in both sites detects as many infections as using two separate slides.
BACKGROUND AND OBJECTIVES: Adolescent girls may have isolated asymptomatic urethral Chlamydia trachomatis infection. GOAL OF THIS STUDY: To determine if a single direct fluorescent antibody (DFA) slide can detect as many urethral and cervical infections as the use of separate slides and to determine if isolated urethral infection occurs. STUDY DESIGN: During pelvic examinations upon admission, DFA slides were prepared from the cervix, from the urethra, and with cells from both sites. RESULTS: Of 125 girls, 17 had C. trachomatis infection: 4 in the urethra only (24%), 5 in the cervical sample only (31%), 5 in both sites (31%), 3 had positive results only on the combined slide, and 1 had a positive result on the cervical slide and an inadequate urethral slide. CONCLUSION: Isolated urethral C. trachomatis infection occurs frequently, and sampling both sites as opposed to sampling the cervix alone increases the number of cases found by 24% (P < 0.002). Using a single slide to detect infection in both sites detects as many infections as using two separate slides.
Authors: C A Gaydos; C P Cartwright; P Colaninno; J Welsch; J Holden; S Y Ho; E M Webb; C Anderson; R Bertuzis; L Zhang; T Miller; G Leckie; K Abravaya; J Robinson Journal: J Clin Microbiol Date: 2010-07-28 Impact factor: 5.948
Authors: W H Goessens; J W Mouton; W I van der Meijden; S Deelen; T H van Rijsoort-Vos; N Lemmens-den Toom; H A Verbrugh; R P Verkooyen Journal: J Clin Microbiol Date: 1997-10 Impact factor: 5.948
Authors: Stephanie N Taylor; Barbara Van Der Pol; Rebecca Lillis; Edward W Hook; William Lebar; Thomas Davis; Deanna Fuller; Leandro Mena; Paul Fine; Charlotte A Gaydos; David H Martin Journal: Sex Transm Dis Date: 2011-07 Impact factor: 2.830
Authors: J Debattista; P Martin; J Jamieson; K Crane; I Dolton; S Russell-Hall; J DeSilva; R Hargrave; T Robinson; N Ryan; M Mortlock Journal: Sex Transm Infect Date: 2002-06 Impact factor: 3.519
Authors: M A Chernesky; D Jang; H Lee; J D Burczak; H Hu; J Sellors; S J Tomazic-Allen; J B Mahony Journal: J Clin Microbiol Date: 1994-11 Impact factor: 5.948
Authors: Charlotte A Gaydos; Barbara Van Der Pol; Mary Jett-Goheen; Mathilda Barnes; Nicole Quinn; Carey Clark; Grace E Daniel; Paula B Dixon; Edward W Hook Journal: J Clin Microbiol Date: 2013-03-06 Impact factor: 5.948