| Literature DB >> 8188737 |
L J van Warmerdam1, W W ten Bokkel Huinink, R A Maes, J H Beijnen.
Abstract
Pharmacokinetic parameters of antineoplastic drugs are usually generated from concentration/time profiles obtained after multiple venipunctures. With limited-sampling models (LSM) this number can be reduced to between one and three timed plasma samples. LSMs may facilitate population pharmacokinetic/pharmacodynamic studies, which eventually may lead to a dosing strategy based on the characteristics of the individual patient. In this article, the development, validation and application of several LSMs reported in the literature are reviewed.Entities:
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Year: 1994 PMID: 8188737 DOI: 10.1007/bf01240143
Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN: 0171-5216 Impact factor: 4.553