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Literature DB >> 8168812

Incidence of chromosome 18 disomy in human sperm nuclei as detected by nonisotopic in situ hybridization.

Abstract

Nonradioactive in situ hybridization with an alpha-satellite DNA probe specific for chromosome 18 was performed on human interphase sperm nuclei to detect the frequency of sperm cells disomic for chromosome 18. A total of 16,127 sperm heads from eight healthy donors, aged 23-57 years, was investigated, and a minimum of 2000 sperm nuclei per proband was analyzed. The disomy rate ranged from 0.25% to 0.5%, with an average of 0.36%. This frequency does not differ significantly from that determined for other chromosomes.

Entities: Species

Mesh：

Substances：
DNA Probes
Isotopes

Year: 1994 PMID： 8168812 DOI： 10.1007/bf00201667

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

18 in total

1. Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes.

Authors: R H Martin; E Ko; A Rademaker
Journal: Am J Med Genet Date: 1991-06-01

2. Non-isotopic detection of chromosome 1 in human meiosis and demonstration of disomic sperm nuclei.

Authors: M Guttenbach; M Schmid
Journal: Hum Genet Date: 1991-07 Impact factor: 4.132

3. Origin of the extra chromosome in trisomy 18. A study on five patients using a restriction fragment length polymorphism.

Authors: T Kondoh; H Tonoki; T Matsumoto; M Tsukahara; N Niikawa
Journal: Hum Genet Date: 1988-08 Impact factor: 4.132

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Authors: K G Kupke; U Müller
Journal: Am J Hum Genet Date: 1989-10 Impact factor: 11.025

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Authors: X Ya-gang; W P Robinson; R Spiegel; F Binkert; U Ruefenacht; A A Schinzel
Journal: Clin Genet Date: 1993-08 Impact factor: 4.438

6. Rates of chromosome abnormalities at different maternal ages.

Authors: E B Hook
Journal: Obstet Gynecol Date: 1981-09 Impact factor: 7.661

Review 7. Trisomy in man.

Authors: T J Hassold; P A Jacobs
Journal: Annu Rev Genet Date: 1984 Impact factor: 16.830

8. The frequency of aneuploidy among individual chromosomes in 6,821 human sperm chromosome complements.

Authors: R H Martin; A Rademaker
Journal: Cytogenet Cell Genet Date: 1990

9. Incidence of chromosome aberrations among 11148 newborn children.

Authors: J Nielsen; I Sillesen
Journal: Humangenetik Date: 1975-10-20

10. Nonisotopic in situ hybridization as a method for nondisjunction studies in human spermatozoa.

Authors: E Coonen; M H Pieters; J C Dumoulin; H Meyer; J L Evers; F C Ramaekers; J P Geraedts
Journal: Mol Reprod Dev Date: 1991-01 Impact factor: 2.609

5 in total

1. Fluorescence in situ hybridization with chromosome paint probes: a novel approach to assess aneuploidy in human sperm nuclei.

Authors: N Rives; S Wust; B David; V Duchesne; G Joly; B Mace
Journal: J Assist Reprod Genet Date: 1999-01 Impact factor: 3.412