Literature DB >> 8164737

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.

D Kägi1, B Ledermann, K Bürki, P Seiler, B Odermatt, K J Olsen, E R Podack, R M Zinkernagel, H Hengartner.   

Abstract

Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CD8+ cytolytic T cells and natural killer cells are mediated by pore formation involving perforin. These mice are viable and fertile and have normal numbers of CD8+ T cells and natural killer cells which do not lyse virus-infected or allogeneic fibroblasts or natural killer target cells in vitro. The mice fail to clear lymphocytic choriomeningitis virus and they eliminate fibrosarcoma tumour cells with reduced efficiency. Perforin is therefore a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

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Year:  1994        PMID： 8164737     DOI： 10.1038/369031a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  511 in total

1.  Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.

Authors:  K A Browne; E Blink; V R Sutton; C J Froelich; D A Jans; J A Trapani
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

2.  Gamma interferon expression in CD8(+) T cells is a marker for circulating cytotoxic T lymphocytes that recognize an HLA A2-restricted epitope of human cytomegalovirus phosphoprotein pp65.

Authors:  S A Ghanekar; L E Nomura; M A Suni; L J Picker; H T Maecker; V C Maino
Journal:  Clin Diagn Lab Immunol       Date:  2001-05

3.  Induction of antiviral antibodies by DNA immunization requires neither perforin-mediated nor CD8(+)-T-cell-mediated lysis of antigen-expressing cells.

Authors:  D E Hassett; J Zhang; J L Whitton
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

4.  How to induce involuntary suicide: the need for dipeptidyl peptidase I.

Authors:  E R Podack
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

5.  Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.

Authors:  P Seiler; B M Senn; P Klenerman; U Kalinke; H Hengartner; R M Zinkernagel
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

6.  Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization.

Authors:  D E Hassett; J Zhang; M Slifka; J L Whitton
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

7.  Viral persistence in vivo through selection of neutralizing antibody-escape variants.

Authors:  A Ciurea; P Klenerman; L Hunziker; E Horvath; B M Senn; A F Ochsenbein; H Hengartner; R M Zinkernagel
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

Review 8.  A portrait of the Bcl-2 protein family: life, death, and the whole picture.

Authors:  M Pellegrini; A Strasser
Journal:  J Clin Immunol       Date:  1999-11       Impact factor: 8.317

9.  Involvement of decidual Valpha14 NKT cells in abortion.

Authors:  K Ito; M Karasawa; T Kawano; T Akasaka; H Koseki; Y Akutsu; E Kondo; S Sekiya; K Sekikawa; M Harada; M Yamashita; T Nakayama; M Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

10.  Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system.

Authors:  B Parra; M T Lin; S A Stohlman; C C Bergmann; R Atkinson; D R Hinton
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103
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