Literature DB >> 10639149

Involvement of decidual Valpha14 NKT cells in abortion.

K Ito1, M Karasawa, T Kawano, T Akasaka, H Koseki, Y Akutsu, E Kondo, S Sekiya, K Sekikawa, M Harada, M Yamashita, T Nakayama, M Taniguchi.   

Abstract

The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Valpha14 NKT cells expressing an invariant antigen receptor encoded by Valpha14/Jalpha281 and Vbeta7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with alpha-galactosylceramide (alpha-GalCer), a specific ligand for Valpha14 NKT cells. The alpha-GalCer-mediated abortion was not observed in Valpha14 NKT-, IFN-gamma-, tumor necrosis factor alpha-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated Valpha14 NKT cells whose perforin-dependent killing and production of IFN-gamma and tumor necrosis factor alpha were essential. The possible role of the decidual Valpha14 NKT cells in the pathogenesis of abortion is discussed.

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Year:  2000        PMID： 10639149      PMCID： PMC15400          DOI： 10.1073/pnas.97.2.740

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  Phenotypes and invariant alpha beta TCR expression of peripheral V alpha 14+ NK T cells.

Authors:  K Masuda; Y Makino; J Cui; T Ito; T Tokuhisa; Y Takahama; H Koseki; K Tsuchida; T Koike; H Moriya; M Amano; M Taniguchi
Journal:  J Immunol       Date:  1997-03-01       Impact factor: 5.422

2.  A sensitive method for analyzing beta-galactosidase reporter gene expression in tissue sections of mouse embryos.

Authors:  A Lazik; Y Liu; P Bringas; F Sangiorgi; R Maxson
Journal:  Trends Genet       Date:  1996-11       Impact factor: 11.639

3.  IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau.

Authors:  G Chaouat; A Assal Meliani; J Martal; R Raghupathy; J F Elliott; J Elliot; T Mosmann; T G Wegmann
Journal:  J Immunol       Date:  1995-05-01       Impact factor: 5.422

4.  Predominant expression of invariant V alpha 14+ TCR alpha chain in NK1.1+ T cell populations.

Authors:  Y Makino; R Kanno; T Ito; K Higashino; M Taniguchi
Journal:  Int Immunol       Date:  1995-07       Impact factor: 4.823

5.  Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.

Authors:  M Taniguchi; H Koseki; T Tokuhisa; K Masuda; H Sato; E Kondo; T Kawano; J Cui; A Perkes; S Koyasu; Y Makino
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

6.  T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.

Authors:  L Krishnan; L J Guilbert; T G Wegmann; M Belosevic; T R Mosmann
Journal:  J Immunol       Date:  1996-01-15       Impact factor: 5.422

7.  Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines.

Authors:  L Krishnan; L J Guilbert; A S Russell; T G Wegmann; T R Mosmann; M Belosevic
Journal:  J Immunol       Date:  1996-01-15       Impact factor: 5.422

8.  The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts.

Authors:  Y Y Yu; T George; J R Dorfman; J Roland; V Kumar; M Bennett
Journal:  Immunity       Date:  1996-01       Impact factor: 31.745

9.  Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts.

Authors:  J Yui; M Garcia-Lloret; T G Wegmann; L J Guilbert
Journal:  Placenta       Date:  1994-12       Impact factor: 3.481
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  35 in total

1.  CD1d and invariant NKT cells at the human maternal-fetal interface.

Authors:  Jonathan E Boyson; Basya Rybalov; Louise A Koopman; Mark Exley; Steven P Balk; Frederick K Racke; Frederick Schatz; Rachel Masch; S Brian Wilson; Jack L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-04       Impact factor: 11.205

2.  The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.

Authors:  Michael T Wilson; Cecilia Johansson; Danyvid Olivares-Villagómez; Avneesh K Singh; Aleksandar K Stanic; Chyung-Ru Wang; Sebastian Joyce; Mary Jo Wick; Luc Van Kaer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

Review 3.  Going both ways: immune regulation via CD1d-dependent NKT cells.

Authors:  Dale I Godfrey; Mitchell Kronenberg
Journal:  J Clin Invest       Date:  2004-11       Impact factor: 14.808

4.  CD1d-restricted NKT cells modulate placental and uterine leukocyte populations during chlamydial infection in mice.

Authors:  Mohamed Habbeddine; Philippe Verbeke; Christiane Delarbre; René Moutier; Stéphane Prieto; David M Ojcius; Colette Kanellopoulos-Langevin
Journal:  Microbes Infect       Date:  2013-08-31       Impact factor: 2.700

Review 5.  NKT cells at the maternal-fetal interface.

Authors:  J E Boyson; I Aktan; D A Barkhuff; A Chant
Journal:  Immunol Invest       Date:  2008       Impact factor: 3.657

6.  Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.

Authors:  Ralf Geiben-Lynn; John R Greenland; Kwesi Frimpong-Boateng; Norman L Letvin
Journal:  J Biol Chem       Date:  2009-10-15       Impact factor: 5.157

7.  Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice.

Authors:  H J Blumenfeld; R Tohn; S M M Haeryfar; Y Liu; P B Savage; T L Delovitch
Journal:  Clin Exp Immunol       Date:  2011-10       Impact factor: 4.330

8.  IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.

Authors:  Tsuyoshi Ota; Kazuyoshi Takeda; Hisaya Akiba; Yoshihiro Hayakawa; Kouetsu Ogasawara; Yoshinori Ikarashi; Sachiko Miyake; Hiro Wakasugi; Takashi Yamamura; Mitchell Kronenberg; David H Raulet; Katsuyuki Kinoshita; Hideo Yagita; Mark J Smyth; Ko Okumura
Journal:  Blood       Date:  2005-03-03       Impact factor: 22.113

9.  Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.

Authors:  Sungjune Kim; Saif Lalani; Vrajesh V Parekh; Tiffaney L Vincent; Lan Wu; Luc Van Kaer
Journal:  J Clin Invest       Date:  2008-06       Impact factor: 14.808

10.  Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss.

Authors:  Jonathan E Boyson; Nisha Nagarkatti; Leena Nizam; Mark A Exley; Jack L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-14       Impact factor: 11.205
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