Literature DB >> 8088289

Preparation and clinical evaluation of technetium-99m dimercaptosuccinic acid for tumour scintigraphy.

T Hirano1, K Tomiyoshi, Y J Zhang, T Ishida, T Inoue, K Endo.   

Abstract

We describe a simple method of pentavalent technetium-99m dimercaptosuccinic acid [99mTc(V)-DMSA] preparation for the imaging of medullary carcinoma of the thyroid using commercially available kits. 99mTc(V)-DMSA is available at high pH (approximately 7.5) by adding NaHCO3 solution in the presence of a small amount of reducing agent (SnCl2). On the other hand, trivalent 99mTc-DMSA [99mTc(III)-DMSA] can be obtained at low pH (below 3) in the presence of an excess amount of reducing agent. In the clinical evaluation of a patient with a medullary carcinoma of the thyroid, only 99mTc(V)-DMSA revealed an area of intense accumulation.

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Year:  1994        PMID： 8088289     DOI： 10.1007/bf00182308

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  10 in total

1.  Pentavalent [99mTc]DMSA, [131I]MIBG, and [99mTc]MDP--an evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid.

Authors:  S E Clarke; C R Lazarus; P Wraight; C Sampson; M N Maisey
Journal:  J Nucl Med       Date:  1988-01       Impact factor: 10.057

2.  Technetium-99m DMSA uptake by metastatic carcinoma of the prostate.

Authors:  O Jeghers; N Puttemans; D Urbain; H R Ham
Journal:  J Nucl Med       Date:  1986-07       Impact factor: 10.057

3.  A comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans.

Authors:  H Ohta; M Ishii; M Yoshizumi; K Endo; H Sakahara; T Nakajima; I Yomoda; H Masuda; K Horiuchi; N Hata
Journal:  Clin Nucl Med       Date:  1985-03       Impact factor: 7.794

4.  A new imaging agent for medullary carcinoma of the thyroid.

Authors:  H Ohta; K Yamamoto; K Endo; T Mori; D Hamanaka; A Shimazu; K Ikekubo; K Makimoto; Y Iida; J Konishi
Journal:  J Nucl Med       Date:  1984-03       Impact factor: 10.057

5.  Scintigraphy and treatment of medullary carcinoma of the thyroid with iodine-131 metaiodobenzylguanidine.

Authors:  S E Clarke; C R Lazarus; S Edwards; B Murby; D G Clarke; T M Roden; I Fogelman; M N Maisey
Journal:  J Nucl Med       Date:  1987-12       Impact factor: 10.057

6.  Preparation of technetium-99-DMS renal complex in solution and its chemical and biological characterization.

Authors:  N Vanlić-Razumenić; J Petrović
Journal:  Int J Appl Radiat Isot       Date:  1982-04

7.  The chemical identity of pentavalent technetium-99m-dimercaptosuccinic acid.

Authors:  P J Blower; J Singh; S E Clarke
Journal:  J Nucl Med       Date:  1991-05       Impact factor: 10.057

8.  Clinical evaluation of tumour imaging using 99Tc(V)m dimercaptosuccinic acid, a new tumour-seeking agent.

Authors:  H Ohta; K Endo; T Fujita; J Konishi; K Torizuka; K Horiuchi; A Yokoyama
Journal:  Nucl Med Commun       Date:  1988-02       Impact factor: 1.690

Review 9.  Iodine-131 MIBG uptake in metastatic medullary carcinoma of the thyroid. A patient treated with somatostatin.

Authors:  C A Keeling; L V Basso
Journal:  Clin Nucl Med       Date:  1988-04       Impact factor: 7.794

10.  A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA).

Authors:  G Westera; A Gadze; W Horst
Journal:  Int J Appl Radiat Isot       Date:  1985-04
  10 in total
  4 in total

1.  Pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT: does it have a place in predicting survival in patients with glioblastoma multiforme?

Authors:  Amr Amin; M Mustafa; E Abd El-Hadi; A Monier; A Badwey; E Saad
Journal:  J Neurooncol       Date:  2014-10-28       Impact factor: 4.130

2.  Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results.

Authors:  Amr Amin; Hosna Moustafa; Ebaa Ahmed; Mohamed El-Toukhy
Journal:  J Neurooncol       Date:  2011-09-13       Impact factor: 4.130

3.  Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.

Authors:  H Kobayashi; K H Suzuki; H Sakahara; Z S Yao; A Yokoyama; J Konishi
Journal:  Eur J Nucl Med       Date:  1995-06

4.  Scintigraphic detection of recurrence of medullary thyroid cancer.

Authors:  M Koizumi; Y Yamada; E Nomura; M Amano; Y Okajima; H Okizuka; K Yamada; S Sawano; T Kitahara; T Yamashita
Journal:  Ann Nucl Med       Date:  1995-05       Impact factor: 2.668
  4 in total

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