Literature DB >> 7556304

Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.

H Kobayashi1, K H Suzuki, H Sakahara, Z S Yao, A Yokoyama, J Konishi.   

Abstract

It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (99mTc (V) DMSA) can be changed into 99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of 99mTc. The method of labelling of 99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated 99mTc (III) DMSA into 99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.

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Year:  1995        PMID： 7556304     DOI： 10.1007/bf00817283

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Pentavalent [99mTc]DMSA, [131I]MIBG, and [99mTc]MDP--an evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid.

Authors:  S E Clarke; C R Lazarus; P Wraight; C Sampson; M N Maisey
Journal:  J Nucl Med       Date:  1988-01       Impact factor: 10.057

2.  [The development of new tumor imaging 99mTc (V)-DMS kit: preparation and labeling condition studies].

Authors:  I Yomoda; K Horiuchi; N Hata; H Masuda; A Yokoyama; H Ogawa; N Nakazawa; T Ooi
Journal:  Kaku Igaku       Date:  1987-01

3.  A comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans.

Authors:  H Ohta; M Ishii; M Yoshizumi; K Endo; H Sakahara; T Nakajima; I Yomoda; H Masuda; K Horiuchi; N Hata
Journal:  Clin Nucl Med       Date:  1985-03       Impact factor: 7.794

4.  The design of a pentavalent 99mTc-dimercaptosuccinate complex as a tumor imaging agent.

Authors:  A Yokoyama; N Hata; K Horiuchi; H Masuda; H Saji; H Ohta; K Yamamoto; K Endo; K Torizuka
Journal:  Int J Nucl Med Biol       Date:  1985

5.  Chemical and biological studies on 99mTc-DMS--II: Effect of Sn(II) on the formation of various Tc-DMS complexes.

Authors:  I Ikeda; O Inoue; K Kurata
Journal:  Int J Appl Radiat Isot       Date:  1976-12

6.  A new imaging agent for medullary carcinoma of the thyroid.

Authors:  H Ohta; K Yamamoto; K Endo; T Mori; D Hamanaka; A Shimazu; K Ikekubo; K Makimoto; Y Iida; J Konishi
Journal:  J Nucl Med       Date:  1984-03       Impact factor: 10.057

7.  Preparation and clinical evaluation of technetium-99m dimercaptosuccinic acid for tumour scintigraphy.

Authors:  T Hirano; K Tomiyoshi; Y J Zhang; T Ishida; T Inoue; K Endo
Journal:  Eur J Nucl Med       Date:  1994-01

8.  Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy.

Authors:  H Kobayashi; H Sakahara; M Hosono; M Shirato; K Endo; Y Kotoura; T Yamamuro; J Konishi
Journal:  Radiology       Date:  1994-01       Impact factor: 11.105

9.  A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA).

Authors:  G Westera; A Gadze; W Horst
Journal:  Int J Appl Radiat Isot       Date:  1985-04
  9 in total
  2 in total

1.  Skeletal affinity of Tc(V)-DMS is bone cell mediated and pH dependent.

Authors:  Kazuko Horiuchi-Suzuki; Aya Konno; Mayumi Ueda; Yoko Fukuda; Saori Nishio; Kazuyuki Hashimoto; Hideo Saji
Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-11-29       Impact factor: 9.236

2.  Assessment of tracer 99mTc(V)-DMSA uptake as a measure of tumor cell proliferation in vitro.

Authors:  Fatma J Al-Saeedi; Princy M Mathew; Yunus A Luqmani
Journal:  PLoS One       Date:  2013-01-15       Impact factor: 3.240
  2 in total

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