Literature DB >> 8045572

Sublocalization of a locus at 3p21.3-23 predisposing to hereditary nonpolyposis colon cancer.

P Tannergård1, E Zabarovsky, E Stanbridge, M Nordenskjöld, A Lindblom.   

Abstract

Hereditary nonpolyposis colon cancer (HNPCC) is a heterogeneous disease caused by at least three different genes on chromosomes 2 and 3, and one or more additional chromosomes. We used 19 dinucleotide markers in order to sublocalize further the 3p locus linked to HNPCC, and to order the markers into one map resulting in a panel of markers suitable for linkage studies. Human chromosome 3 mouse hybrids were used to determine the chromosomal position of the markers. Haplotype analysis in two families where the disease is linked to chromosome 3p21-23 was used in order to sublocalize further the region in which the gene is located. Based on our results, the gene has now been localized to the region 3p21.3-23.

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Year:  1994        PMID： 8045572     DOI： 10.1007/bf00202874

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Transfer and selective retention of single specific human chromosomes via microcell-mediated chromosome transfer.

Authors:  P J Saxon; E J Stanbridge
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

2.  Genetic mapping of a locus predisposing to human colorectal cancer.

Authors:  P Peltomäki; L A Aaltonen; P Sistonen; L Pylkkänen; J P Mecklin; H Järvinen; J S Green; J R Jass; J L Weber; F S Leach
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

3.  Report and abstracts of the Fourth International Workshop on Human Chromosome 3 Mapping.

Authors:  S L Naylor; C H Buys; B Carritt
Journal:  Cytogenet Cell Genet       Date:  1994

Review 4.  Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review.

Authors:  H T Lynch; T C Smyrk; P Watson; S J Lanspa; J F Lynch; P M Lynch; R J Cavalieri; C R Boland
Journal:  Gastroenterology       Date:  1993-05       Impact factor: 22.682

5.  Alu-PCR approach to isolating NotI-linking clones from the 3p14-p21 region frequently deleted in renal cell carcinoma.

Authors:  E R Zabarovsky; V I Kashuba; E S Pokrovskaya; V I Zabarovska; J Y Wang; P Berglund; F Boldog; E J Stanbridge; J Sumegi; G Klein
Journal:  Genomics       Date:  1993-06       Impact factor: 5.736

6.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

Authors:  R Fishel; M K Lescoe; M R Rao; N G Copeland; N A Jenkins; J Garber; M Kane; R Kolodner
Journal:  Cell       Date:  1993-12-03       Impact factor: 41.582

7.  Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p.

Authors:  M H Jones; K Yamakawa; Y Nakamura
Journal:  Hum Mol Genet       Date:  1992-05       Impact factor: 6.150

8.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

Authors:  F S Leach; N C Nicolaides; N Papadopoulos; B Liu; J Jen; R Parsons; P Peltomäki; P Sistonen; L A Aaltonen; M Nyström-Lahti
Journal:  Cell       Date:  1993-12-17       Impact factor: 41.582

9.  Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer.

Authors:  A Lindblom; P Tannergård; B Werelius; M Nordenskjöld
Journal:  Nat Genet       Date:  1993-11       Impact factor: 38.330
  9 in total
  4 in total

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3.  Yeast artificial chromosome cloning of the beta-catenin locus on human chromosome 3p21-22.

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Review 4.  From APC to the genetics of hereditary and familial colon cancer syndromes.

Authors:  Alisa P Olkinuora; Päivi T Peltomäki; Lauri A Aaltonen; Kristiina Rajamäki
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  4 in total

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