| Literature DB >> 7780664 |
A Bailey1, A L Norris, J P Leek, P M Clissold, I M Carr, D J Ogilvie, J F Morrison, D M Meredith, A F Markham.
Abstract
beta-Catenin has emerged as an important component of the adherens junctions between epithelial cells. As a result of studies of its interaction with the APC gene product, it has been implicated in the development of colorectal cancer. alpha-Catenin, beta-catenin, E-cadherin and APC appear to mediate contact inhibition in epithelia. As part of the study of the organization of the beta-catenin gene, we have isolated yeast artificial chromosomes (YACs) to characterize its intron/exon structure. YAC fluorescence in situ hybridization analysis and polymerase chain reaction analysis of somatic cell hybrid DNAs show that beta-catenin maps in the 3p21-22 region, the location of tumour-suppressor genes deleted in small-cell lung cancer (SCLC) and other disorders. beta-Catenin YACs will provide a source of microsatellite markers useful in loss of heterozygosity studies to assess the importance of beta-catenin deletions in SCLC.Entities:
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Year: 1995 PMID： 7780664 DOI： 10.1007/bf00710714
Source DB: PubMed Journal: Chromosome Res ISSN： 0967-3849 Impact factor: 5.239