Literature DB >> 1301149

Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p.

M H Jones1, K Yamakawa, Y Nakamura.   

Abstract

We have screened cosmids on chromosome 3p for (dC-dA)n.(dG-dT)n dinucleotide-repeat sequences. Eighty-nine of 155 cosmids (58%) contained (dC-dA)n.(dG-dT(n repeats as determined by colony hybridization with a (dG-dT)10 oligonucleotide probe; 29 of these were subcloned and the sequences flanking the dinucleotide repeats were determined. Nineteen of the 24 loci examined for polymorphisms by PCR were found to be polymorphic with heterozygosities ranging from 3% to 86%. These dinucleotide repeat polymorphisms will be useful markers for high-resolution mapping of genes that have been localized to 3p, including tumour suppressor genes associated with several types of cancer and genes responsible for various hereditary disorders, such as von Hippel-Lindau disease.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1301149     DOI： 10.1093/hmg/1.2.131

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  21 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

2.  Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system.

Authors:  S Gläsker; B U Bender; T W Apel; V van Velthoven; L M Mulligan; J Zentner; H P Neumann
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-05       Impact factor: 10.154

3.  Colorectal neoplasms detected colonoscopically in at-risk members of colorectal cancer families stratified by the demonstration of DNA microsatellite instability.

Authors:  J R Jass; V Pokos; J L Arnold; D S Cottier; P Jeevaratnam; N S Van de Water; P J Browett; I M Winship; M R Lane
Journal:  J Mol Med (Berl)       Date:  1996-09       Impact factor: 4.599

Review 4.  Central nervous system manifestations in VHL: genetics, pathology and clinical phenotypic features.

Authors:  Sven Gläsker
Journal:  Fam Cancer       Date:  2005       Impact factor: 2.375

5.  Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors.

Authors:  J Zedenius; G Wallin; A Svensson; J Bovèe; A Höög; M Bäckdahl; C Larsson
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

6.  Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect.

Authors:  H Brauch; T Kishida; D Glavac; F Chen; F Pausch; H Höfler; F Latif; M I Lerman; B Zbar; H P Neumann
Journal:  Hum Genet       Date:  1995-05       Impact factor: 4.132

7.  Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.

Authors:  M A Pericak-Vance; K J Nunes; E Whisenant; D B Loeb; K W Small; J M Stajich; J B Rimmler; L H Yamaoka; D I Smith; H A Drabkin
Journal:  J Med Genet       Date:  1993-06       Impact factor: 6.318

8.  Linkage analysis and allelic imbalance in human breast cancer kindreds using microsatellite markers from the short arm of chromosome 3.

Authors:  J T Bergthorsson; G Eiriksdottir; R B Barkardottir; V Egilsson; A Arason; S Ingvarsson
Journal:  Hum Genet       Date:  1995-10       Impact factor: 4.132

9.  Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.

Authors:  P A Crossey; K Foster; F M Richards; M E Phipps; F Latif; K Tory; M H Jones; E Bentley; R Kumar; M I Lerman
Journal:  Hum Genet       Date:  1994-01       Impact factor: 4.132

10.  Sublocalization of a locus at 3p21.3-23 predisposing to hereditary nonpolyposis colon cancer.

Authors:  P Tannergård; E Zabarovsky; E Stanbridge; M Nordenskjöld; A Lindblom
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.