| Literature DB >> 7903889 |
A Lindblom1, P Tannergård, B Werelius, M Nordenskjöld.
Abstract
Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one additional locus may cause HNPCC. We now present tight linkage between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and find that these families also manifest signs of a general DNA replication disorder.Entities:
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Year: 1993 PMID： 7903889 DOI： 10.1038/ng1193-279
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330