Literature DB >> 8031326

Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases.

U Thull1, B Testa.   

Abstract

A number of unsubstituted aromatic hydrocarbons, azaheterocycles, oxaheterocycles and cyclic ketones were screened for their inhibitory potency towards monoamine oxidases (MAO; EC 1.4.3.4.) A and B. Fair activities (IC50 10-100 microM) and selectivities were found for, e.g. naphthalene, anthracene, phenanthrene, isoquinoline and acridine. The most active inhibitors are oxygen-containing compounds (e.g. coumarin, flavone, dibenzofuran, xanthene, thioxanthone and acridone), with xanthone emerging as a potent (IC50 0.8 microM) and reversible MAO-A inhibitor. All tested inhibitors seem to act in a reversible and time-independent manner.

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Year:  1994        PMID： 8031326     DOI： 10.1016/0006-2952(94)90271-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  9 in total

1.  Crystal structure of 10-benzyl-9-(3,4-di-meth-oxy-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.

Authors:  N Sureshbabu; V Sughanya
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-08-26

2.  In vitro techniques for studying drug metabolism.

Authors:  F P Guengerich
Journal:  J Pharmacokinet Biopharm       Date:  1996-10

3.  Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships.

Authors:  T Grandi; F Sparatore; C Gnerre; P Crivori; P A Carrupt; B Testa
Journal:  AAPS PharmSci       Date:  1999

4.  Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system.

Authors:  Gabriela Sabrina Anzollin; Lilian Zaki; Thalita Maria Perin; Bruna Finger; Letícia Trentin Perin; Fernanda Petry; Thalia Sebulsqui Saraiva; Maria Luiza Lima da Costa Lopes; Andresa Heemann Betti; Jaqueline Scapinello; J Vladimir Oliveira; Jacir Dal Magro; Liz G Müller
Journal:  J Tradit Complement Med       Date:  2021-08-30

5.  9-(4-Fluoro-phen-yl)-3,3,6,6-tetra-methyl-10-p-tolyl-1,2,3,4,5,6,7,8,9,10-deca-hydroacridine-1,8-dione.

Authors:  Ziqiang Tang; Changning Liu; Shanshan Wu; Wenjuan Hao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-30

6.  A facile synthesis of N-H- and N-substituted acridine-1,8-diones under sonic condition.

Authors:  S Sudha; M A Pasha
Journal:  ScientificWorldJournal       Date:  2013-12-31

7.  In vitro Antioxidant and Enzymatic Approaches to Evaluate Neuroprotector Potential of Blechnum Extracts without Cytotoxicity to Human Stem Cells.

Authors:  Juliana Maria de Mello Andrade; Renata Biegelmeyer; Roger Remy Dresch; Natasha Maurmann; Patrícia Pranke; Amélia T Henriques
Journal:  Pharmacogn Mag       Date:  2016 Jul-Sep       Impact factor: 1.085

8.  Crystal structure, Hirshfeld surface and frontier mol-ecular orbital analysis of 10-benzyl-9-(4-hydroxy-3-meth-oxy-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.

Authors:  V Sughanya; B Loganathan; D Praveenkumar; J Ayyappan; M L Sundararajan; A Prabhakaran; A Dhandapani; N Suresh Babu
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-07-14

9.  10-Benzyl-9-(4-eth-oxy-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.

Authors:  V Sughanya; N Sureshbabu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-23
  9 in total

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