Literature DB >> 11741212

Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships.

T Grandi1, F Sparatore, C Gnerre, P Crivori, P A Carrupt, B Testa.   

Abstract

Benzazoles containing two or three nitrogen atoms were screened for their inhibitory activity toward monoamine oxidases MAO-A and MAO-B. In order to clarify the mechanism of interaction of these compounds with the enzyme, their electronic structure was calculated at the ab initio level and the influence of lipophilicity on activity was investigated. The mode of binding of benzazoles to MAO-B appears different from that of previously investigated heterocycles.

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Year:  1999        PMID： 11741212      PMCID： PMC2751346          DOI： 10.1208/ps010416

Source DB:  PubMed          Journal:  AAPS PharmSci        ISSN： 1522-1059


  7 in total

1.  A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine.

Authors:  H WEISSBACH; T E SMITH; J W DALY; B WITKOP; S UDENFRIEND
Journal:  J Biol Chem       Date:  1960-04       Impact factor: 5.157

2.  Predominant expression of monoamine oxidase B isoform in rabbit renal proximal tubule: regulation by I2 imidazoline ligands in intact cells.

Authors:  C Gargalidis-Moudanos; A Remaury; N Pizzinat; A Parini
Journal:  Mol Pharmacol       Date:  1997-04       Impact factor: 4.436

3.  [Preparation of variously substituted beta-benzotriazolylbutyric acids with potential choleretic activity].

Authors:  G Paglietti; F Sparatore
Journal:  Farmaco Sci       Date:  1972-05

Review 4.  Molecular basis of human MAO A and B.

Authors:  J C Shih
Journal:  Neuropsychopharmacology       Date:  1991-01       Impact factor: 7.853

5.  The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Authors:  K Castagnoli; S Palmer; A Anderson; T Bueters; N Castagnoli
Journal:  Chem Res Toxicol       Date:  1997-04       Impact factor: 3.739

6.  Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases.

Authors:  U Thull; B Testa
Journal:  Biochem Pharmacol       Date:  1994-06-15       Impact factor: 5.858

7.  Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors.

Authors:  U Thull; S Kneubühler; B Testa; M F Borges; M M Pinto
Journal:  Pharm Res       Date:  1993-08       Impact factor: 4.200
  7 in total
  2 in total

1.  Detecting local heterogeneity and ionization ability in the head group region of different lipidic phases using modified fluorescent probes.

Authors:  Osama K Abou-Zied; N Idayu Zahid; M Faisal Khyasudeen; David S Giera; Julian C Thimm; Rauzah Hashim
Journal:  Sci Rep       Date:  2015-03-03       Impact factor: 4.379

2.  Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors.

Authors:  Nafiz Öncü Can; Ulviye Acar Çevik; Begüm Nurpelin Sağlık; Yusuf Özkay; Özlem Atlı; Merve Baysal; Ümide Demir Özkay; Özgür Devrim Can
Journal:  Molecules       Date:  2017-08-19       Impact factor: 4.411
  2 in total

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