PURPOSE: Better prognostic predictors in colorectal cancer than the Dukes stage are necessary for individualized therapy and follow-up. METHODS: Survival among 212 patients operated on for colorectal cancer was examined regarding various clinical, histopathologic, cellular, and serologic tumor characteristics. RESULTS: Beside the Dukes stage, which was the most powerful variable, the erythrocyte sedimentation rate, leukocyte blood count, alkaline phosphatase, aspartate aminotransferase, six different serum tumor markers, number of small blood vessels, and age were found to be significantly associated with survival. The leukocyte blood count, alkaline phosphatase, and aspartate aminotransferase retained their significance in a multivariate model including tumor differentiation, local tumor stage, and age. Inclusion of tissue polypeptide antigen, the most powerful tumor marker in the multivariate model, showed that only the tumor stage, tissue polypeptide antigen, and age were statistically significantly correlated to survival. This was valid both for the group of patients considered as potentially curable and for those who potentially have been cured (Dukes Stages A-C). CONCLUSIONS: A great number of prognostic predictors failed to discard Dukes stage as the best one. One serum tumor marker, tissue polypeptide antigen, contains independent additional prognostic information.
PURPOSE: Better prognostic predictors in colorectal cancer than the Dukes stage are necessary for individualized therapy and follow-up. METHODS: Survival among 212 patients operated on for colorectal cancer was examined regarding various clinical, histopathologic, cellular, and serologic tumor characteristics. RESULTS: Beside the Dukes stage, which was the most powerful variable, the erythrocyte sedimentation rate, leukocyte blood count, alkaline phosphatase, aspartate aminotransferase, six different serum tumor markers, number of small blood vessels, and age were found to be significantly associated with survival. The leukocyte blood count, alkaline phosphatase, and aspartate aminotransferase retained their significance in a multivariate model including tumor differentiation, local tumor stage, and age. Inclusion of tissue polypeptide antigen, the most powerful tumor marker in the multivariate model, showed that only the tumor stage, tissue polypeptide antigen, and age were statistically significantly correlated to survival. This was valid both for the group of patients considered as potentially curable and for those who potentially have been cured (Dukes Stages A-C). CONCLUSIONS: A great number of prognostic predictors failed to discard Dukes stage as the best one. One serum tumor marker, tissue polypeptide antigen, contains independent additional prognostic information.
Authors: Yang Hyun Cho; Jun Eul Hwang; Ho Seok Chung; Myung Soo Kim; Eu Chang Hwang; Seung Il Jung; Taek Won Kang; Dong Deuk Kwon; Seock Hwan Choi; Hyun Tae Kim; Tae-Hwan Kim; Tae Gyun Kwon; Joon Hwa Noh; Myung Ki Kim; Chul-Sung Kim; Sung Gu Kang; Seok Ho Kang; Jun Cheon; Chan Ho Lee; Ja Yoon Ku; Hong Koo Ha; Bum Sik Tae; Chang Wook Jeong; Ja Hyeon Ku; Cheol Kwak; Hyeon Hoe Kim Journal: Int Urol Nephrol Date: 2017-05-08 Impact factor: 2.370
Authors: Hui Ling; Karen Pickard; Cristina Ivan; Alex Mirnezami; George A Calin; Milena S Nicoloso; Claudio Isella; Mariko Ikuo; Richard Mitter; Riccardo Spizzo; Marc Bullock; Cornelia Braicu; Valentina Pileczki; Kimberly Vincent; Martin Pichler; Verena Stiegelbauer; Gerald Hoefler; Maria I Almeida; Annie Hsiao; Xinna Zhang; John Primrose; Graham Packham; Kevin Liu; Krishna Bojja; Roberta Gafà; Lianchun Xiao; Simona Rossi; Jian H Song; Ivan Vannini; Francesca Fanini; Scott Kopetz; Patrick Zweidler-McKay; Xuemei Wang; Calin Ionescu; Alexandru Irimie; Muller Fabbri; Giovanni Lanza; Stanley R Hamilton; Ioana Berindan-Neagoe; Enzo Medico Journal: Gut Date: 2015-03-24 Impact factor: 23.059