Yang Hyun Cho1, Jun Eul Hwang2, Ho Seok Chung1, Myung Soo Kim1, Eu Chang Hwang3, Seung Il Jung1, Taek Won Kang1, Dong Deuk Kwon1, Seock Hwan Choi4, Hyun Tae Kim4, Tae-Hwan Kim4, Tae Gyun Kwon4, Joon Hwa Noh5, Myung Ki Kim6, Chul-Sung Kim7, Sung Gu Kang8, Seok Ho Kang8, Jun Cheon8, Chan Ho Lee9, Ja Yoon Ku9, Hong Koo Ha9, Bum Sik Tae10, Chang Wook Jeong10, Ja Hyeon Ku10, Cheol Kwak10, Hyeon Hoe Kim10. 1. Department of Urology, Chonnam National University Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Korea. 2. Department of Hemato-Oncology, Chonnam National University Medical School, Gwangju, Korea. 3. Department of Urology, Chonnam National University Medical School, 42 Jebongro, Donggu, Gwangju, 501-757, Korea. urohwang@gmail.com. 4. Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea. 5. Department of Urology, Kwangju Christian Hospital, Gwangju, Korea. 6. Department of Urology, Chonbuk National University Medical School, Jeonju, Korea. 7. Department of Urology, Chosun University School of Medicine, Gwangju, Korea. 8. Department of Urology, Korea University College of Medicine, Seoul, Korea. 9. Department of Urology, Pusan National University School of Medicine, Busan, Korea. 10. Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
PURPOSE: Recently, several studies have shown that the De Ritis ratio (aspartate transaminase/alanine transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma. METHODS: In total, 1049 patients who underwent RNU at eight institutions from 2004 to 2015 were reviewed retrospectively. The De Ritis ratio and conventional clinicopathological parameters were analyzed. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariate analysis was carried out using the Cox proportional hazards regression model. De Ritis ratio cutoff values were derived from receiver operating characteristic (ROC) curves. RESULTS: ROC analysis showed the cutoff De Ritis ratio for overall death to be 1.6 (p = 0.002). The cancer-specific survival (CSS) and overall survival (OS) were significantly shorter for patients with a high De Ritis ratio (>1.6). Multivariate analysis revealed an independent relationship between an increased De Ritis ratio (>1.6) and shorter CSS (hazard ratio, HR 2.49, 95% confidence interval, CI 1.70-3.64; p = 0.001) and OS (HR 1.84, 95% CI 1.34-2.52; p = 0.001). CONCLUSION: The De Ritis ratio can be a significant predictor of oncological outcomes in patients with upper urinary tract urothelial carcinoma after surgery.
PURPOSE: Recently, several studies have shown that the De Ritis ratio (aspartate transaminase/alanine transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma. METHODS: In total, 1049 patients who underwent RNU at eight institutions from 2004 to 2015 were reviewed retrospectively. The De Ritis ratio and conventional clinicopathological parameters were analyzed. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariate analysis was carried out using the Cox proportional hazards regression model. De Ritis ratio cutoff values were derived from receiver operating characteristic (ROC) curves. RESULTS: ROC analysis showed the cutoff De Ritis ratio for overall death to be 1.6 (p = 0.002). The cancer-specific survival (CSS) and overall survival (OS) were significantly shorter for patients with a high De Ritis ratio (>1.6). Multivariate analysis revealed an independent relationship between an increased De Ritis ratio (>1.6) and shorter CSS (hazard ratio, HR 2.49, 95% confidence interval, CI 1.70-3.64; p = 0.001) and OS (HR 1.84, 95% CI 1.34-2.52; p = 0.001). CONCLUSION: The De Ritis ratio can be a significant predictor of oncological outcomes in patients with upper urinary tract urothelial carcinoma after surgery.
Authors: Giovanni Lughezzani; Maximilian Burger; Vitaly Margulis; Surena F Matin; Giacomo Novara; Morgan Roupret; Shahrokh F Shariat; Christopher G Wood; Richard Zigeuner Journal: Eur Urol Date: 2012-02-23 Impact factor: 20.096
Authors: Angelika Bezan; Edvin Mrsic; Daniel Krieger; Tatjana Stojakovic; Karl Pummer; Richard Zigeuner; Georg C Hutterer; Martin Pichler Journal: J Urol Date: 2015-01-23 Impact factor: 7.450