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Literature DB >> 7961443

rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshift.

B Larsen¹, N M Wills, R F Gesteland, J F Atkins.

Abstract

Base pairing between the 3' end of 16S rRNA and mRNA is shown to be important for the programmed -1 frameshifting utilized in decoding the Escherichia coli dnaX gene. This pairing is the same as the Shine-Dalgarno pairing used by prokaryotic ribosomes in selection of translation initiators, but for frameshifting the interaction occurs within elongating ribosomes. For dnaX -1 frameshifting, the 3' base of the Shine-Dalgarno sequence is 10 nucleotides 5' of the shift site. Previously, Shine-Dalgarno rRNA-mRNA pairing was shown to stimulate the +1 frameshifting necessary for decoding the release factor 2 gene. However, in the release factor 2 gene, the Shine-Dalgarno sequence is located 3 nucleotides 5' of the shift site. When the Shine-Dalgarno sequence is moved to the same position relative to the dnaX shift site, it is inhibitory rather than stimulatory. Shine-Dalgarno interactions by elongating ribosomes are likely to be used in stimulating -1 frameshifting in the decoding of a variety of genes.

Entities: Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7961443 PMCID： PMC197052 DOI： 10.1128/jb.176.22.6842-6851.1994

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

40 in total

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Journal: Mol Microbiol Date: 1992-05 Impact factor: 3.501

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Journal: J Mol Biol Date: 1979-03-15 Impact factor: 5.469

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7. Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo.

Authors: N T Parkin; M Chamorro; H E Varmus
Journal: J Virol Date: 1992-08 Impact factor: 5.103

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Authors: C S Chiou; A L Jones
Journal: J Bacteriol Date: 1993-02 Impact factor: 3.490

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Journal: Proc Natl Acad Sci U S A Date: 1974-04 Impact factor: 11.205

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Authors: P Somogyi; A J Jenner; I Brierley; S C Inglis
Journal: Mol Cell Biol Date: 1993-11 Impact factor: 4.272

75 in total

1. Programmed +1 frameshifting stimulated by complementarity between a downstream mRNA sequence and an error-correcting region of rRNA.

Authors: Z Li; G Stahl; P J Farabaugh
Journal: RNA Date: 2001-02 Impact factor: 4.942

Review 2. P-site tRNA is a crucial initiator of ribosomal frameshifting.

Authors: Pavel V Baranov; Raymond F Gesteland; John F Atkins
Journal: RNA Date: 2004-02 Impact factor: 4.942

3. Sequences that direct significant levels of frameshifting are frequent in coding regions of Escherichia coli.

Authors: Olga L Gurvich; Pavel V Baranov; Jiadong Zhou; Andrew W Hammer; Raymond F Gesteland; John F Atkins
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

4. -1 frameshifting at a CGA AAG hexanucleotide site is required for transposition of insertion sequence IS1222.

Authors: Nina Mejlhede; Patricia Licznar; Marie-Françoise Prère; Norma M Wills; Raymond F Gesteland; John F Atkins; Olivier Fayet
Journal: J Bacteriol Date: 2004-05 Impact factor: 3.490

5. A -1 ribosomal frameshift in the transcript that encodes the major head protein of bacteriophage A2 mediates biosynthesis of a second essential component of the capsid.

Authors: Pilar García; Isabel Rodríguez; Juan E Suárez
Journal: J Bacteriol Date: 2004-03 Impact factor: 3.490