Literature DB >> 7957048

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

L F Reis1, H Ruffner, G Stark, M Aguet, C Weissmann.   

Abstract

The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid of functional IRF-1 by targeted gene disruption. As reported by others, IRF-1-deficient mice showed a discrete phenotype: the CD4/CD8 ratio was increased and IFN-gamma-induced levels of macrophage iNO synthase mRNA were strongly diminished. However, type I IFN induction in vivo by virus or double-stranded RNA was unimpaired, as evidenced by serum IFN titers and IFN mRNA levels in spleen, liver and lung. There was also no impairment in the response of type I IFN-inducible genes. Therefore, IRF-1 is not essential for these processes in vivo.

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Year:  1994        PMID： 7957048      PMCID： PMC395418          DOI： 10.1002/j.1460-2075.1994.tb06805.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  44 in total

1.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

2.  Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production.

Authors:  P B Sehgal; B Dobberstein; I Tamm
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

3.  Activation of the human beta-interferon gene requires an interferon-inducible factor.

Authors:  T Enoch; K Zinn; T Maniatis
Journal:  Mol Cell Biol       Date:  1986-03       Impact factor: 4.272

4.  Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.

Authors:  N B Raj; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

5.  Regulation of cellular interferon production: enhancement by antimetabolites.

Authors:  Y H Tan; J A Armstrong; Y H Ke; M Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

6.  Functional role of type I and type II interferons in antiviral defense.

Authors:  U Müller; U Steinhoff; L F Reis; S Hemmi; J Pavlovic; R M Zinkernagel; M Aguet
Journal:  Science       Date:  1994-06-24       Impact factor: 47.728

7.  Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature.

Authors:  J Vilcek; E A Havell
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

8.  Differential effect of poly rI.rC and Newcastle disease virus on the expression of interferon and cellular genes in mouse cells.

Authors:  K A Kelley; P M Pitha
Journal:  Virology       Date:  1985-12       Impact factor: 3.616

9.  Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.

Authors:  H Weber; D Valenzuela; G Lujber; M Gubler; C Weissmann
Journal:  EMBO J       Date:  1987-03       Impact factor: 11.598

10.  Superinduction of the human interferon-beta promoter.

Authors:  H Dinter; H Hauser
Journal:  EMBO J       Date:  1987-03       Impact factor: 11.598
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  67 in total

1.  Role for p53 in gene induction by double-stranded RNA.

Authors:  B T Hummer; X L Li; B A Hassel
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

2.  Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors.

Authors:  Shin Sasaki; Rama Rao Amara; Wen-Shuz Yeow; Paula M Pitha; Harriet L Robinson
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

3.  Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.

Authors:  Matthias Farlik; Birgit Rapp; Isabelle Marie; David E Levy; Amanda M Jamieson; Thomas Decker
Journal:  Mol Cell Biol       Date:  2012-01-17       Impact factor: 4.272

4.  Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.

Authors:  Z W Li; G Stark; J Götz; T Rülicke; M Gschwind; G Huber; U Müller; C Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

Review 5.  The IRF family, revisited.

Authors:  A Paun; P M Pitha
Journal:  Biochimie       Date:  2007-02-20       Impact factor: 4.079

6.  Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI.

Authors:  Pamela D Winterberg; Yanxia Wang; Keng-Mean Lin; John R Hartono; Glenn T Nagami; Xin J Zhou; John M Shelton; James A Richardson; Christopher Y Lu
Journal:  Am J Physiol Renal Physiol       Date:  2013-05-08

7.  Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.

Authors:  I Marié; J E Durbin; D E Levy
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598

8.  An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression.

Authors:  V Kiermer; C Van Lint; D Briclet; C Vanhulle; R Kettmann; E Verdin; A Burny; L Droogmans
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

9.  Identification and characterization of interferon regulatory factor-1 from orange-spotted grouper (Epinephelus coioides).

Authors:  Yan Shi; Xin-Ping Zhu; Jing-Kui Yin; Qi-Ya Zhang; Jian-Fang Gui
Journal:  Mol Biol Rep       Date:  2009-05-15       Impact factor: 2.316

10.  Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.

Authors:  Y T Juang; W Lowther; M Kellum; W C Au; R Lin; J Hiscott; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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