Literature DB >> 3034596

Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.

H Weber, D Valenzuela, G Lujber, M Gubler, C Weissmann.   

Abstract

Human IFN-alpha 1 and IFN-alpha 2 differ in 28 of 166 amino acids and show very different specific antiviral activities on human and murine cells. We have identified, by hybrid scanning and site-directed mutagenesis, three residues in IFN-alpha 2, in positions 121, 125 and 132 which, when replaced individually or jointly by their IFN-alpha 1 counterparts, modify its activity on mouse cells by up to 400-fold. We argue that these residues are involved in direct contacts with the mouse interferon receptor.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3034596      PMCID： PMC553438          DOI： 10.1002/j.1460-2075.1987.tb04795.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  20 in total

1.  Chou-Fasman analysis of the secondary structure of F and Le interferons.

Authors:  T G Hayes
Journal:  Biochem Biophys Res Commun       Date:  1980-07-31       Impact factor: 3.575

2.  The 5'-flanking region of a human IFN-alpha gene mediates viral induction of transcription.

Authors:  U Weidle; C Weissmann
Journal:  Nature       Date:  1983 Jun 2-8       Impact factor: 49.962

3.  A single amino acid change in IFN-beta1 abolishes its antiviral activity.

Authors:  H M Shepard; D Leung; N Stebbing; D V Goeddel
Journal:  Nature       Date:  1981-12-10       Impact factor: 49.962

4.  Possible conformation of interferons: a prediction based on amino acid composition and sequence.

Authors:  V P Zav'yalov; A I Denesyuk
Journal:  Immunol Lett       Date:  1982-01       Impact factor: 3.685

5.  Specific molecular activities of recombinant and hybrid leukocyte interferons.

Authors:  E Rehberg; B Kelder; E G Hoal; S Pestka
Journal:  J Biol Chem       Date:  1982-10-10       Impact factor: 5.157

6.  Various human interferon alpha subclasses cross-react with common receptors: their binding affinities correlate with their specific biological activities.

Authors:  M Aguet; M Gröbke; P Dreiding
Journal:  Virology       Date:  1984-01-15       Impact factor: 3.616

7.  Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.

Authors:  H Weber; C Weissmann
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971

8.  Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

Authors:  M Streuli; A Hall; W Boll; W E Stewart; S Nagata; C Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

9.  Antiviral activities of hybrids of two major human leukocyte interferons.

Authors:  P K Weck; S Apperson; N Stebbing; P W Gray; D Leung; H M Shepard; D V Goeddel
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

10.  Improved plasmid vectors with a thermoinducible expression and temperature-regulated runaway replication.

Authors:  E Remaut; H Tsao; W Fiers
Journal:  Gene       Date:  1983-04       Impact factor: 3.688
View more
  31 in total

1.  MyoD-dependent induction during myoblast differentiation of p204, a protein also inducible by interferon.

Authors:  C j Liu; H Wang; Z Zhao; S Yu; Y B Lu; J Meyer; G Chatterjee; S Deschamps; B A Roe; P Lengyel
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription.

Authors:  C J Liu; H Wang; P Lengyel
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

Review 3.  The cellular receptor of the alpha-beta interferons.

Authors:  K E Mogensen; G Uzé; P Eid
Journal:  Experientia       Date:  1989-06-15

4.  Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response.

Authors:  D Garcin; J Curran; M Itoh; D Kolakofsky
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

5.  Inhibition of E2F-mediated transcription by p202.

Authors:  D Choubey; S J Li; B Datta; J U Gutterman; P Lengyel
Journal:  EMBO J       Date:  1996-10-15       Impact factor: 11.598

6.  Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor.

Authors:  M A Garcia-Blanco; P Lengyel; E Morrison; C Brownlee; C D Stiles; M Rutherford; G Hannigan; B R Williams
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

7.  A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment.

Authors:  Anje Cauwels; Sandra Van Lint; Geneviève Garcin; Jennyfer Bultinck; Franciane Paul; Sarah Gerlo; José Van der Heyden; Yann Bordat; Dominiek Catteeuw; Lode De Cauwer; Elke Rogge; Annick Verhee; Gilles Uzé; Jan Tavernier
Journal:  Oncoimmunology       Date:  2017-11-27       Impact factor: 8.110

8.  Herpes simplex virus pathogenesis in transgenic mice is altered by the homeodomain protein Hox 1.3.

Authors:  W J Mitchell; R J De Santo; S D Zhang; W F Odenwald; H Arnheiter
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

9.  The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.

Authors:  W Min; S Ghosh; P Lengyel
Journal:  Mol Cell Biol       Date:  1996-01       Impact factor: 4.272

10.  The amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling.

Authors:  Dominique Garcin; Jean-Baptiste Marq; Stephen Goodbourn; Daniel Kolakofsky
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.