Literature DB >> 7947546

Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS.

S K Akula1, P E Ma, G A Peyman, M H Rahimy, N E Hyslop, A Janney, P Ashton.   

Abstract

To study its safety and efficacy in treating cytomegalovirus (CMV) retinitis, an AIDS patient received an intravitreal injection of liposome encapsulated ganciclovir in the right eye. The left eye served as a control, receiving intravitreal free ganciclovir. The right eye showed no retinal haemorrhages or detachment; however, vision declined initially, stabilising later. Weekly examination showed neither progression of the CMV retinitis nor new lesions in the right eye. The left eye showed reactivation of old CMV retinitis. Liposome encapsulated ganciclovir reduced the number of intravitreal injections, stabilising CMV retinitis, and warrants further study.

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Year:  1994        PMID： 7947546      PMCID： PMC504904          DOI： 10.1136/bjo.78.9.677

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  20 in total

1.  Long-term intravitreal ganciclovir therapy for cytomegalovirus retinopathy.

Authors:  M H Heinemann
Journal:  Arch Ophthalmol       Date:  1989-12

2.  Intravitreal sustained-release ganciclovir.

Authors:  T J Smith; P A Pearson; D L Blandford; J D Brown; K A Goins; J L Hollins; E T Schmeisser; P Glavinos; L B Baldwin; P Ashton
Journal:  Arch Ophthalmol       Date:  1992-02

3.  Intravitreal ganciclovir in CMV retinitis: case report.

Authors:  M L Harris; M B Mathalone
Journal:  Br J Ophthalmol       Date:  1989-05       Impact factor: 4.638

4.  Efficacy of liposome-bound amphotericin B for the treatment of experimental fungal endophthalmitis in rabbits.

Authors:  K R Liu; G A Peyman; B Khoobehi
Journal:  Invest Ophthalmol Vis Sci       Date:  1989-07       Impact factor: 4.799

5.  Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.

Authors:  M A Jacobson; J J O'Donnell; J Mills
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

6.  A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome.

Authors:  W R Freeman; C W Lerner; J A Mines; R S Lash; A J Nadel; M B Starr; M L Tapper
Journal:  Am J Ophthalmol       Date:  1984-02       Impact factor: 5.258

7.  Infections associated with Hickman catheters in patients with acquired immunodeficiency syndrome.

Authors:  M C Raviglione; R Battan; A Pablos-Mendez; P Aceves-Casillas; M P Mullen; A Taranta
Journal:  Am J Med       Date:  1989-06       Impact factor: 4.965

8.  Efficacy and tolerance of intravitreal ganciclovir in cytomegalovirus retinitis in acquired immune deficiency syndrome.

Authors:  I Cochereau-Massin; P Lehoang; M Lautier-Frau; L Zazoun; P Marcel; M Robinet; S Matheron; C Katlama; S Gharakhanian; W Rozenbaum
Journal:  Ophthalmology       Date:  1991-09       Impact factor: 12.079

9.  Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device.

Authors:  G E Sanborn; R Anand; R E Torti; S D Nightingale; S X Cal; B Yates; P Ashton; T Smith
Journal:  Arch Ophthalmol       Date:  1992-02

10.  Evaluation of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis.

Authors:  V S Rao; G A Peyman; B Khoobehi; S Vangipuram
Journal:  Int Ophthalmol       Date:  1989-05       Impact factor: 2.031
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  5 in total

Review 1.  Nanocarriers of nanotechnology in retinal diseases.

Authors:  Ali M Al-Halafi
Journal:  Saudi J Ophthalmol       Date:  2014-03-05

Review 2.  Liposomes and nanotechnology in drug development: focus on ocular targets.

Authors:  Miki Honda; Tomohiro Asai; Naoto Oku; Yoshihiko Araki; Minoru Tanaka; Nobuyuki Ebihara
Journal:  Int J Nanomedicine       Date:  2013-02-14

Review 3.  Management of cytomegalovirus corneal endotheliitis.

Authors:  Angela H Y Wong; Wee Nie Kua; Alvin L Young; Kelvin H Wan
Journal:  Eye Vis (Lond)       Date:  2021-01-14

4.  Safety and Tolerability of Topical Ophthalmic Triamcinolone Acetonide-Loaded Liposomes Formulation and Evaluation of Its Biologic Activity in Patients with Diabetic Macular Edema.

Authors:  Jose Navarro-Partida; Juan Carlos Altamirano-Vallejo; Alejandro Gonzalez-De la Rosa; Juan Armendariz-Borunda; Carlos Rodrigo Castro-Castaneda; Arturo Santos
Journal:  Pharmaceutics       Date:  2021-03-02       Impact factor: 6.321

Review 5.  Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches.

Authors:  Emily Dosmar; Julia Walsh; Michael Doyel; Katlynn Bussett; Adekite Oladipupo; Sabri Amer; Katherine Goebel
Journal:  Bioengineering (Basel)       Date:  2022-01-17
  5 in total

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