Literature DB >> 2793311

Evaluation of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis.

V S Rao1, G A Peyman, B Khoobehi, S Vangipuram.   

Abstract

We investigated the effects of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis induced in rabbits. Clindamycin was encapsulated into liposomes, and suspended in two concentrations: 1 mg/0.1 ml and 2 mg/0.1 ml of clindamycin phosphate. Seven eyes received an intravitreal injection (0.1 ml volume) containing 1 mg of liposome-encapsulated clindamycin and seven eyes received 2 mg. Three control rabbits (six eyes) received drug-free liposomes (three eyes) and no treatment (three eyes). All but one eye treated with clindamycin recovered. All control eyes, including those treated with empty liposomes, were lost to infection.

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Year:  1989        PMID： 2793311     DOI： 10.1007/bf02028207

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN： 0165-5701            Impact factor:   2.031


  17 in total

1.  Drug entrapment in liposomes.

Authors:  G Gregoriadis
Journal:  FEBS Lett       Date:  1973-11-01       Impact factor: 4.124

2.  Intravitreal administration of antibiotic in the treatment of bacterial endophthalmitis. III. Consensus.

Authors:  J Baum; G A Peyman; M Barza
Journal:  Surv Ophthalmol       Date:  1982 Jan-Feb       Impact factor: 6.048

3.  Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits.

Authors:  C Tremblay; M Barza; F Szoka; M Lahav; J Baum
Journal:  Invest Ophthalmol Vis Sci       Date:  1985-05       Impact factor: 4.799

4.  Pharmacokinetics of liposome-encapsulated anti-tumor drugs. Studies with vinblastine, actinomycin D, cytosine arabinoside, and daunomycin.

Authors:  R L Juliano; D Stamp
Journal:  Biochem Pharmacol       Date:  1978-01-01       Impact factor: 5.858

5.  The effect of entrapment in liposomes on the in vivo distribution of [3H]methotrexate in a primate.

Authors:  H K Kimelberg; T F Tracy; S M Biddlecome; R S Bourke
Journal:  Cancer Res       Date:  1976-08       Impact factor: 12.701

6.  Lectin-mediated attachment of liposomes to cornea: influence on transcorneal drug flux.

Authors:  H E Schaeffer; J M Breitfeller; D L Krohn
Journal:  Invest Ophthalmol Vis Sci       Date:  1982-10       Impact factor: 4.799

7.  Liposomes in topical drug delivery.

Authors:  H E Schaeffer; D L Krohn
Journal:  Invest Ophthalmol Vis Sci       Date:  1982-02       Impact factor: 4.799

8.  Management of infectious endophthalmitis.

Authors:  R K Forster; R L Abbott; H Gelender
Journal:  Ophthalmology       Date:  1980-04       Impact factor: 12.079

9.  Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

Authors:  F Szoka; D Papahadjopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

10.  Intravitreal liposome-encapsulated gentamicin in a rabbit model. Prolonged therapeutic levels.

Authors:  P H Fishman; G A Peyman; T Lesar
Journal:  Invest Ophthalmol Vis Sci       Date:  1986-07       Impact factor: 4.799
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  6 in total

Review 1.  Liposomes as delivery systems in the prevention and treatment of infectious diseases.

Authors:  J J Bergers; T L ten Hagen; E W van Etten; I A Bakker-Woudenberg
Journal:  Pharm World Sci       Date:  1995-01-27

2.  Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS.

Authors:  S K Akula; P E Ma; G A Peyman; M H Rahimy; N E Hyslop; A Janney; P Ashton
Journal:  Br J Ophthalmol       Date:  1994-09       Impact factor: 4.638

3.  Intravitreal liposome-encapsulated drugs: a preliminary human report.

Authors:  G A Peyman; H C Charles; K R Liu; B Khoobehi; M Niesman
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

Review 4.  Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential.

Authors:  G Gregoriadis; A T Florence
Journal:  Drugs       Date:  1993-01       Impact factor: 9.546

5.  Design and development of intraocular polymeric implant systems for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis.

Authors:  Lana Tamaddon; S Abolfazl Mostafavi; Reza Karkhane; Mohammad Riazi-Esfahani; Farid Abedin Dorkoosh; Morteza Rafiee-Tehrani
Journal:  Adv Biomed Res       Date:  2015-01-30

6.  Thermoanalytical characterization of clindamycin-loaded intravitreal implants prepared by hot melt extrusion.

Authors:  Lana Tamaddon; Seyed Abolfazl Mostafavi; Reza Karkhane; Mohammad Riazi-Esfahani; Farid Abedin Dorkoosh; Morteza Rafiee-Tehrani
Journal:  Adv Biomed Res       Date:  2015-07-27
  6 in total

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